Poly I-C

Known as: 5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acid homopolymer (1:1), polyinosate-polycytidylate, polyinosate.polycytidylate 
A synthetic polyinosinic-polycytidylic acid double-stranded RNA. Poly IC may stimulate the release of cytotoxic cytokines and, by inducing interferon… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1940-2017
010020030019402016

Papers overview

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Highly Cited
2008
Highly Cited
2008
The ribonucleic acid (RNA) helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5… (More)
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Highly Cited
2008
Highly Cited
2008
In acute promyelocytic leukaemia (APL), the promyelocytic leukaemia (PML) protein is fused to the retinoic acid receptor α (RAR… (More)
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Highly Cited
2006
Highly Cited
2006
Host genetic factors that regulate innate immunity determine susceptibility to sepsis. Disruption of nuclear factor-erythroid 2… (More)
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Highly Cited
2005
Highly Cited
2005
Innate cellular antiviral defenses are likely to influence the outcome of infections by many human viruses, including hepatitis B… (More)
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Highly Cited
2004
Highly Cited
2004
Microglia are the resident macrophage-like population in the CNS. Microglia remain quiescent until injury or infection activates… (More)
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Highly Cited
2003
Highly Cited
2003
Maternal viral infection is known to increase the risk for schizophrenia and autism in the offspring. Using this observation in… (More)
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Highly Cited
2001
Highly Cited
2001
Toll-like receptors (TLRs) are a family of innate immune-recognition receptors that recognize molecular patterns associated with… (More)
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Highly Cited
1996
Highly Cited
1996
T cell proliferation in vivo is presumed to reflect a T cell receptor (TCR)-mediated polyclonal response directed to various… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND AND PURPOSE The purpose of the present study was to evaluate a modified method of intraluminal suture occlusion of the… (More)
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Highly Cited
1992
Highly Cited
1992
Programmed cell death (PCD) plays a key role in developmental biology and in maintenance of the steady state in continuously… (More)
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