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Poly I-C

Known as: 5'-Inosinic acid, homopolymer, complex with 5'-cytidylic acid homopolymer (1:1), polyinosate-polycytidylate, polyinosate.polycytidylate 
A synthetic polyinosinic-polycytidylic acid double-stranded RNA. Poly IC may stimulate the release of cytotoxic cytokines and, by inducing interferon… 
National Institutes of Health

Related topics

Related topics

15 relations

Broader (3)

Antiviral AgentsInterferon InducersPolynucleotides
In BloodNCIt Antineoplastic Agent TerminologyProcess of secretionagonists

Narrower (4)

Rintatolimodpoly I-5-mercapto-poly Cpoly IC-polylysine carboxymethyl dextranpoly ICLC

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Self-assembled polyethylenimine-graft-poly(ε-caprolactone) micelles as potential dual carriers of genes and anticancer drugs
Highly Cited
2005
Highly Cited
2005
Toll-like receptor 3 ligand attenuates LPS-induced liver injury by down-regulation of toll-like receptor 4 expression on macrophages.
This study demonstrates that pretreatment with polyinosinic-polycytidylic acid (poly I:C) significantly decreased the mortality… 
Highly Cited
2003
Highly Cited
2003
Curvature-Directed Crystallization of Poly(vinylidene difluoride) in Nanotube Walls
Poly(vinylidene difluoride) (PVDF) nanotubes were prepared by wetting of ordered porous templates. We processed either PVDF melts… 
Highly Cited
1999
Highly Cited
1999
Local Presentation of Substrate Molecules Directs Axon Specification by Cultured Hippocampal Neurons
Axon specification is a crucial, early step in neuronal development, but little is known about how this event is controlledin… 
Highly Cited
1999
Highly Cited
1999
ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2.
The survival of type 2 alveolar epithelial cells (AEC2) in the lung after hyperoxic injury is regulated by signals from the… 
Highly Cited
1998
Highly Cited
1998
The Reactive Polymeric Micelle Based on An Aldehyde-Ended Poly(ethylene glycol)/Poly(lactide) Block Copolymer
Formation of amphiphilic poly(ethylene glycol)-b-polylactide (PEG/PLA) block copolymers was accomplished by using potassium… 
Highly Cited
1994
Highly Cited
1994
The P-selectin glycoprotein ligand from human neutrophils displays sialylated, fucosylated, O-linked poly-N-acetyllactosamine.
We previously demonstrated that P-selectin binds with high affinity to a trace, homodimeric glycoprotein ligand on human myeloid… 
Highly Cited
1993
Highly Cited
1993
L-14 lectin recognition of laminin and its promotion of in vitro cell adhesion.
The S-type lactose-binding lectins are found in a variety of animal tissues and their primary sequences are highly conserved… 
Highly Cited
1980
Highly Cited
1980
Dysfunction of natural killer cells in multiple sclerosis: a possible pathogenetic factor.
Natural killer (NK) cell activity, antibody-dependent cytotoxicity (ADCC) and the effect of interferon on NK activity was… 
Highly Cited
1970
Highly Cited
1970
Studies on the binding of actinomycin D to DNA and DNA model polymers.
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