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Platelet Glycoprotein GPIIb-IIIa Complex

Known as: Alpha 2b/Beta 3, Glycoprotein IIb/IIIa, Alpha2b/Beta3 
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and… 
National Institutes of Health

Related topics

Related topics

29 relations

Broader (5)

CD AntigensIntegrinsPlatelet Membrane GlycoproteinsSurface Antigens
Cell AdhesionCell Adhesion MoleculesGlycoproteinsITGA2B protein, human

Papers overview

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1998
1998
A recombinant soluble form of the integrin alpha IIb beta 3 (GPIIb-IIIa) assumes an active, ligand-binding conformation and is recognized by GPIIb-IIIa-specific monoclonal, allo-, auto-, and drug…
The IIb-IIIa glycoprotein complex is a favored target for allo-, auto-, and drug-dependent antibodies associated with immune… 
Highly Cited
1997
Highly Cited
1997
A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro.
Glanzmann thrombasthenia, an inherited bleeding disorder, can be caused by a defect or deficiency in platelet integrin alphaIIb… 
Review
1997
Review
1997
Integrin alpha IIb beta 3 and platelet function.
Highly Cited
1994
Highly Cited
1994
The integrin alpha IIb-beta 3, platelet glycoprotein IIb-IIIa, can form a functionally active heterodimer complex without the cysteine-rich repeats of the beta 3 subunit.
Highly Cited
1992
Highly Cited
1992
Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells…
We demonstrate an example of signal transduction by an integrin and have begun to define the pathway through which this signaling… 
Highly Cited
1992
Highly Cited
1992
False-positive flow cytometric platelet glycoprotein IIb/IIIa expression in myeloid leukemias secondary to platelet adherence to blasts.
Because neither morphologic nor routine cytochemical features are pathognomonic, the diagnosis of acute megakaryoblastic leukemia… 
Highly Cited
1991
Highly Cited
1991
A Monoclonal Antibody Against the Platelet Glycoprotein IIb/IIIa Receptor Complex Prevents Platelet Aggregation and Thrombosis in a Canine Model of Coronary Angioplasty
BackgroundThe comparative effects of aspirin and F(ab′)2 fragments of monoclonal antibody 7E3 against the platelet glycoprotein… 
Highly Cited
1990
Highly Cited
1990
Calpain proteolysis of von Willebrand factor enhances its binding to platelet membrane glycoprotein IIb/IIIa: an explanation for platelet aggregation in thrombotic thrombocytopenic purpura
We have previously observed calpain activity (calcium‐dependent cysteine protease) in sera from patients with acute thrombotic… 
Highly Cited
1989
Highly Cited
1989
Immunochemical characterization of the new platelet alloantigen system Bra/Brb
Summary. We report the immunochemical characterization of the new platelet‐specific alloantigens Bra and Brb. Bra antibodies were… 
Highly Cited
1987
Highly Cited
1987
Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets.
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