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Platelet Glycoprotein GPIIb-IIIa Complex

Known as: Alpha 2b/Beta 3, Glycoprotein IIb/IIIa, Alpha2b/Beta3 
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and… 
National Institutes of Health

Related topics

Related topics

29 relations

Broader (5)

CD AntigensIntegrinsPlatelet Membrane GlycoproteinsSurface Antigens
Cell AdhesionCell Adhesion MoleculesGlycoproteinsITGA2B protein, human

Papers overview

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Highly Cited
1997
Highly Cited
1997
Rapid assessment of platelet function with a modified whole-blood aggregometer in percutaneous transluminal coronary angioplasty patients receiving anti-GP IIb/IIIa therapy.
BACKGROUND The glycoprotein (GP) IIb/IIIa receptor antagonist abciximab (c7E3 Fab, ReoPro) is approved for use in high-risk… 
Highly Cited
1997
Highly Cited
1997
A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro.
Glanzmann thrombasthenia, an inherited bleeding disorder, can be caused by a defect or deficiency in platelet integrin alphaIIb… 
Highly Cited
1994
Highly Cited
1994
Platelet adhesion to fibronectin in flow: dependence on surface concentration and shear rate, role of platelet membrane glycoproteins GP IIb/IIIa and VLA-5, and inhibition by heparin.
Platelet adhesion to purified surface-immobilized fibronectin under flow conditions was investigated. Fibronectin was found to… 
Highly Cited
1993
Highly Cited
1993
Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads.
To speed drug discovery, we developed an approach for identification of individual peptides with a desired biological activity… 
Highly Cited
1992
Highly Cited
1992
Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells…
We demonstrate an example of signal transduction by an integrin and have begun to define the pathway through which this signaling… 
Highly Cited
1991
Highly Cited
1991
A Monoclonal Antibody Against the Platelet Glycoprotein IIb/IIIa Receptor Complex Prevents Platelet Aggregation and Thrombosis in a Canine Model of Coronary Angioplasty
BackgroundThe comparative effects of aspirin and F(ab′)2 fragments of monoclonal antibody 7E3 against the platelet glycoprotein… 
Highly Cited
1990
Highly Cited
1990
Calpain proteolysis of von Willebrand factor enhances its binding to platelet membrane glycoprotein IIb/IIIa: an explanation for platelet aggregation in thrombotic thrombocytopenic purpura
We have previously observed calpain activity (calcium‐dependent cysteine protease) in sera from patients with acute thrombotic… 
Highly Cited
1988
Highly Cited
1988
Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex.
Highly Cited
1987
Highly Cited
1987
Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets.
Highly Cited
1986
Highly Cited
1986
Identification of platelet glycoprotein IIb/IIIa as the major binding site for released platelet-von Willebrand factor.
We studied the effects(s) of two monoclonal antibodies, 6D1 and 10E5 (directed against platelet glycoprotein Ib [GPIb] and the… 
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