Platelet Glycoprotein GPIIb-IIIa Complex

Known as: Alpha 2b/Beta 3, Glycoprotein IIb/IIIa, Alpha2b/Beta3 
Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and… (More)
National Institutes of Health

Related topics

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29 relations

Broader (5)

CD AntigensIntegrinsPlatelet Membrane GlycoproteinsSurface Antigens
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Cell AdhesionCell Adhesion MoleculesGlycoproteinsITGA2B protein, human
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Papers overview

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Highly Cited
2002
Highly Cited
2002
Targeted-microbubble binding selectively to GPIIb IIIa receptors of platelet thrombi.
RATIONALE AND OBJECTIVES New targeted microbubbles directed to the GPIIb IIIa receptor have been developed. The objective was to… (More)
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Highly Cited
2001
Highly Cited
2001
Comparison of two platelet glycoprotein IIb/IIIa inhibitors, tirofiban and abciximab, for the prevention of ischemic events with percutaneous coronary revascularization.
BACKGROUND In the setting of percutaneous coronary revascularization, agents in the class known as platelet glycoprotein IIb/IIIa… (More)
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Highly Cited
2000
Highly Cited
2000
Platelet GP IIIa Pl(A) polymorphisms display different sensitivities to agonists.
BACKGROUND Both inherited predisposition and platelet hyperreactivity have been associated with ischemic coronary events, but… (More)
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Highly Cited
1998
Highly Cited
1998
Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody.
T cell proliferative responses to platelet membrane GPIIb-IIIa were examined in 14 patients with chronic immune thrombocytopenic… (More)
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Highly Cited
1997
Highly Cited
1997
Platelet glycoprotein IIb/IIIa receptor blockade and low-dose heparin during percutaneous coronary revascularization.
BACKGROUND Blockade of the platelet glycoprotein IIb/IIIa receptor with abciximab (a monoclonal-antibody Fab fragment directed… (More)
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Highly Cited
1997
Highly Cited
1997
7E3 monoclonal antibody directed against the platelet glycoprotein IIb/IIIa cross-reacts with the leukocyte integrin Mac-1 and blocks adhesion to fibrinogen and ICAM-1.
Recent clinical trials suggest that blockade of integrins is a promising strategy for the treatment of acute coronary syndromes… (More)
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Highly Cited
1996
Highly Cited
1996
A polymorphism of a platelet glycoprotein receptor as an inherited risk factor for coronary thrombosis.
BACKGROUND Platelet glycoprotein IIb/IIIa is a membrane receptor for fibrinogen and von Willebrand factor, and it has an… (More)
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Highly Cited
1994
Highly Cited
1994
Platelet glycoprotein IIb-IIIa and size are increased in acute myocardial infarction.
Platelet aggregation, which plays an important role in acute myocardial infarction (AMI), is mediated by fibrinogen binding to… (More)
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Highly Cited
1985
Highly Cited
1985
A new murine monoclonal antibody reports an activation-dependent change in the conformation and/or microenvironment of the platelet glycoprotein IIb/IIIa complex.
Considerable evidence indicates that the glycoprotein (GP) IIb/IIIa complex on human platelets functions as a receptor for… (More)
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Highly Cited
1984
Highly Cited
1984
Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP.
Chronic idiopathic thrombocytopenic purpura (ITP) is caused by an antibody reactive with platelet-associated antigens. The… (More)
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