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Platelet Glycoprotein GPIIb-IIIa Complex
Known as:
Alpha 2b/Beta 3
, Glycoprotein IIb/IIIa
, Alpha2b/Beta3
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Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and…
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National Institutes of Health
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Related topics
Related topics
29 relations
Broader (5)
CD Antigens
Integrins
Platelet Membrane Glycoproteins
Surface Antigens
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Cell Adhesion
Cell Adhesion Molecules
Glycoproteins
ITGA2B protein, human
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
Rapid assessment of platelet function with a modified whole-blood aggregometer in percutaneous transluminal coronary angioplasty patients receiving anti-GP IIb/IIIa therapy.
M. Mascelli
,
S. Worley
,
+5 authors
R. Jordan
Circulation
1997
Corpus ID: 20746526
BACKGROUND The glycoprotein (GP) IIb/IIIa receptor antagonist abciximab (c7E3 Fab, ReoPro) is approved for use in high-risk…
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Highly Cited
1997
Highly Cited
1997
A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro.
E. Baker
,
E. C. Tozer
,
M. Pfaff
,
S. Shattil
,
J. Loftus
,
M. Ginsberg
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 34992631
Glanzmann thrombasthenia, an inherited bleeding disorder, can be caused by a defect or deficiency in platelet integrin alphaIIb…
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Highly Cited
1994
Highly Cited
1994
Platelet adhesion to fibronectin in flow: dependence on surface concentration and shear rate, role of platelet membrane glycoproteins GP IIb/IIIa and VLA-5, and inhibition by heparin.
S. Beumer
,
M. Ijsseldijk
,
P. G. D. Groot
,
J. Sixma
Blood
1994
Corpus ID: 19318908
Platelet adhesion to purified surface-immobilized fibronectin under flow conditions was investigated. Fibronectin was found to…
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Highly Cited
1993
Highly Cited
1993
Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads.
S. Salmon
,
K. Lam
,
+7 authors
D. Thorpe
Proceedings of the National Academy of Sciences…
1993
Corpus ID: 28221013
To speed drug discovery, we developed an approach for identification of individual peptides with a desired biological activity…
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Highly Cited
1992
Highly Cited
1992
Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells…
A. Pelletier
,
S. Bodary
,
A. Levinson
Molecular Biology of the Cell
1992
Corpus ID: 40567779
We demonstrate an example of signal transduction by an integrin and have begun to define the pathway through which this signaling…
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Highly Cited
1991
Highly Cited
1991
A Monoclonal Antibody Against the Platelet Glycoprotein IIb/IIIa Receptor Complex Prevents Platelet Aggregation and Thrombosis in a Canine Model of Coronary Angioplasty
E. Bates
,
M. J. McGillem
,
J. Mickelson
,
B. Pitt
,
G. Mancini
Circulation
1991
Corpus ID: 10303625
BackgroundThe comparative effects of aspirin and F(ab′)2 fragments of monoclonal antibody 7E3 against the platelet glycoprotein…
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Highly Cited
1990
Highly Cited
1990
Calpain proteolysis of von Willebrand factor enhances its binding to platelet membrane glycoprotein IIb/IIIa: an explanation for platelet aggregation in thrombotic thrombocytopenic purpura
J. Moore
,
W. Murphy
,
J. Kelton
British Journal of Haematology
1990
Corpus ID: 11975601
We have previously observed calpain activity (calcium‐dependent cysteine protease) in sera from patients with acute thrombotic…
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Highly Cited
1988
Highly Cited
1988
Interaction of fibrinogen with its platelet receptor. Differential effects of alpha and gamma chain fibrinogen peptides on the glycoprotein IIb-IIIa complex.
J. Bennett
,
S. Shattil
,
J. Power
,
T. Gartner
Journal of Biological Chemistry
1988
Corpus ID: 34647698
Highly Cited
1987
Highly Cited
1987
Evidence that arginyl-glycyl-aspartate peptides and fibrinogen gamma chain peptides share a common binding site on platelets.
S. Lam
,
E. Plow
,
+4 authors
M. Ginsberg
Journal of Biological Chemistry
1987
Corpus ID: 23632660
Highly Cited
1986
Highly Cited
1986
Identification of platelet glycoprotein IIb/IIIa as the major binding site for released platelet-von Willebrand factor.
R. Parker
,
H. Gralnick
Blood
1986
Corpus ID: 15498486
We studied the effects(s) of two monoclonal antibodies, 6D1 and 10E5 (directed against platelet glycoprotein Ib [GPIb] and the…
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