Skip to search formSkip to main contentSkip to account menu

ITGA2B protein, human

Known as: Platelet Glycoprotein IIb, platelet membrane glycoprotein IIb, human, CD41B antigen, human 
Integrin alpha-IIb (1039 aa, ~113 kDa) is encoded by the human ITGA2B gene. This protein is involved in the mediation of platelet clotting.
National Institutes of Health

Related topics

Related topics

15 relations
Blood coagulationCell AdhesionClusters of differentiationFocal adhesion pathway

Broader (2)

Integrin alpha2Platelet Membrane Glycoprotein IIb

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Engagement of alpha IIb beta 3 (GPIIb/IIIa) with alpha nu beta 3 Integrin Mediates Interaction of Melanoma Cells with Platelets A CONNECTION TO HEMATOGENOUS METASTASIS
1999
1999
The Relations of Major Platelet Receptor Expression during Myocardial Infarction. Monitoring Efficacy of GPIIb/IIIa Inhibitors by Measuring P-selectin?
The Relations of Major Platelet Receptor Expression during Myocardial Infarction. Monitoring Efficacy of GPIIb/IIIa Inhibitors by… 
1998
1998
Platelet Activation and Aggregation Induced by Recombinant von Willebrand Factors Reproducing Four Type 2B von Willebrand Disease Missense Mutations
Summary Type 2B of von Willebrand disease (vWD) refers to qualitative variants with increased affinity of von Willebrand factor… 
1994
1994
An echistatin‐like Arg‐Gly‐Asp (RGD)‐containing sequence in the heavy chain CDR3 of a murine monoclonal antibody that inhibits human platelet glycoprotein IIb/IIIa function
We describe the production and biochemical characterization of the first GPIIb/IIIa‐inhibiting monoclonal antibody that contains… 
1993
1993
A comparative analysis of cDNA-derived sequences for rat and mouse beta 3 integrins (GPIIIA) with their human counterpart.
Alpha IIb beta 3 (GPIIb-IIIa), the platelet receptor for fibrinogen, is a member of the integrin superfamily. We have now cloned… 
Highly Cited
1992
Highly Cited
1992
Molecular basis for Glanzmann's thrombasthenia (GT) in a compound heterozygote with glycoprotein IIb gene: a proposal for the classification of GT based on the biosynthetic pathway of glycoprotein…
The genetic basis for Glanzmann's thrombasthenia (GT) was elucidated on a compound heterozygote with glycoprotein (GP)IIb gene… 
Highly Cited
1991
Highly Cited
1991
Identification of the disulfide bond pattern in albolabrin, an RGD-containing peptide from the venom of Trimeresurus albolabris: significance for the expression of platelet aggregation inhibitory…
Albolabrin is a 73 amino acid peptide isolated from the venom of Trimeresurus albolabris. It contains an RGD sequence and 12… 
1988
1988
Thrombasthenia with an abnormal platelet membrane glycoprotein IIb of different molecular weight.
We describe an individual with abnormal platelet glycoprotein (GP) IIb of different molecular weight (mol wt), a defect that… 
Highly Cited
1986
Highly Cited
1986
Synthesis by cultured human umbilical vein endothelial cells of two proteins structurally and immunologically related to platelet membrane glycoproteins IIb and IIIa
Human platelets participate in a number of adhesive interactions, including binding to exposed subendothelium after vascular… 
1985
1985
Platelet interaction with subendothelial extracellular matrix: platelet-fibrinogen interactions are essential for platelet aggregation but not for the matrix-induced release reaction.
Cultured endothelial cells produce an extracellular matrix (ECM) to which platelets adhere and spread, ultimately resulting in…