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Platelet Activating Factor

Known as: platelet activating factor (PAF), 1 Alkyl 2 acetyl sn glycerophosphocholine, Thrombocyte Aggregating Activity 
A phospholipid derivative formed by PLATELETS; BASOPHILS; NEUTROPHILS; MONOCYTES; and MACROPHAGES. It is a potent platelet aggregating agent and… 
National Institutes of Health

Related topics

Related topics

15 relations

Broader (3)

Blood Coagulation FactorPhospholipid Etherscytokine

Narrower (3)

ONO 6240U 66985dansyl-platelet activating factor
Process of secretionagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Platelet-activating Factor Receptor Activation
Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system results in neuronal apoptosis. Activated HIV… 
Review
1995
Review
1995
Platelet-activating factor antagonists
ConclusionsThe great number of PAF antagonists reviewed in this article clearly shows the tremendous effort made in the last 20… 
Highly Cited
1989
Highly Cited
1989
Amplification of airway constriction due to liquid filling of airway interstices.
Luminal epithelial projections formed during bronchoconstriction define interstices in which liquid can collect. Liquid in these… 
Highly Cited
1988
Highly Cited
1988
Interactions in platelets between G proteins and the agonists that stimulate phospholipase C and inhibit adenylyl cyclase.
Highly Cited
1984
Highly Cited
1984
1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. A common source of platelet-activating factor and arachidonate in human polymorphonuclear leukocytes.
1-O-[3H]Alkyl-2-lyso-sn-glycero-3-phosphocholine (1-O-[3H]alkyl-2-lyso-GPC) incubated with human polymorphonuclear leukocytes… 
Highly Cited
1982
Highly Cited
1982
Vasoactive properties of acetyl glyceryl ether phosphorylcholine and analogues.
Intradermal injection of 0.1 pmole (52 pg.) of acetyl glyceryl ether phosphorylcholine (AGEPC) in guinea pigs induced increased… 
Highly Cited
1981
Highly Cited
1981
Release of platelet-activating factor (PAF) and histamine. II. The cellular origin of human PAF: monocytes, polymorphonuclear neutrophils and basophils.
The origin of platelet activating factor (PAF) from human leucocytes was investigated. Purified monocytes release PAF passively… 
Highly Cited
1981
Highly Cited
1981
Heparin‐induced Thrombocytopenia: Effect of Heparin Platelet Antibody on Platelets
Summary. The plasma of two patients with heparin‐induced thrombocytopenia has been shown to cause platelet aggregation in the… 
Highly Cited
1980
Highly Cited
1980
Platelet‐Activating Factor (PAF‐Acether) Secretion from Platelets: Effect of Aggregating Agents
Platelet‐activating factor is a 1.0‐alkyl‐2 acetyl analogue of phosphatidylcholine (PAF‐acether) which triggers platelet… 
Highly Cited
1977
Highly Cited
1977
Structural analysis of purified platelet-activating factor by lipases
PLATELET-activating factor (PAF) is a newly described mediator of anaphylaxis which has been implicated in the deposition of… 
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