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Human basophil degranulation triggered by very dilute antiserum against IgE
TLDR
When human polymorphonuclear basophils are exposed to anti-IgE antibodies, they release histamine from their intracellular granules and change their staining properties, and transmission of the biological information could be related to the molecular organization of water. Expand
Present concepts on the mechanisms of platelet aggregation.
Raised concentrations of platelet activating factor in colonic mucosa of Crohn's disease patients.
TLDR
The data suggest that platelet activating factor may be involved in the pathogenesis of Crohn's disease and that it could be used as a marker of the mucosal activity of the disease. Expand
Immunoglobulins in intact, immunized, and contaminated axenic mice: study of serum IgA.
TLDR
The effect of prednisolone on serum IgA seemed to be related to passage of IgA from the intestinal system into the blood without true activation of the serum system, which remained undetectable in axenic mice after immunization and at 21 days after contamination. Expand
LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETS THE ROLE OF IGE, BASOPHILS, AND A PLATELET-ACTIVATING FACTOR
We have studied the leukocyte-dependent mechanism of histamine release (LDHR) from rabbit platelets, a complement-independent mechanism which has been implicated in the deposition of immune complexesExpand
Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives.
TLDR
The pharmacological properties of PAF-acether are compatible with its proposed role in the bronchoconstriction of asthma which is probably caused by a still unidentified factor. Expand
Acute circulatory collapse caused by platelet-activating factor (PAF-acether) in dogs.
TLDR
Changes displayed the typical features of common acute circulatory collapse with distributive and hypovolemic etiologies, suggesting that PAF-acether might be an endogenous mediator in the early and late stages of shock. Expand
Structural analysis of purified platelet-activating factor by lipases
TLDR
Results of these experiments suggest that PAF is a 1-lyso-glycerophospholipid, a newly described mediator of anaphylaxis which has been implicated in the deposition of immune complexes in acute serum sickness in rabbits. Expand
Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils
TLDR
Several characteristics of rabbit PAF and a PAF-like factor obtained from human leukocytes are described and direct evidence that this mechanism is due to basophils sensitised with IgE is obtained. Expand
Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988.
TLDR
Analysis of [3H]PAF-acether binding showed that BN 52021 as well as unlabelled PAF-ACether prevented [3h]PAf-ac ether binding to intact washed platelets, which strongly suggested that the mechanism of action of Bn 52021 is of the competitive type. Expand
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