Pinacidil

Known as: Guanidine, N''-cyano-N-4-pyridinyl-N'-(1,2,2-trimethylpropylmonohydrate), (+-)-, Pinacidil [Chemical/Ingredient] 
A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral… (More)
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
BACKGROUND & AIMS Hydrogen sulfide (H(2)S), an endogenous gaseous mediator that causes vasodilation, is generated in mammalian… (More)
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Highly Cited
2004
Highly Cited
2004
Hydrogen sulfide (H2S) has been shown recently to function as an important gasotransmitter. The present study investigated the… (More)
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Highly Cited
2002
Highly Cited
2002
The inwardly rectifying K+ channel Kir6.1 forms K+ channels by coupling with a sulfonylurea receptor in reconstituted systems… (More)
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Highly Cited
2002
Highly Cited
2002
Diazoxide and 5-hydroxydecanoate (5-HD; C10:0) are reputed to target specifically mitochondrial ATP-sensitive K(+) (K(ATP… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND The Brugada syndrome displays an autosomal dominant mode of transmission with low penetrance. Despite equal genetic… (More)
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Highly Cited
2000
Highly Cited
2000
Cardiomyocyte death after ischemia/reperfusion correlates with oxidant stress, and antioxidants confer protection in that model… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND The Brugada syndrome is characterized by marked ST-segment elevation in the right precordial ECG leads and is… (More)
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Highly Cited
1998
Highly Cited
1998
Discovered in the cardiac sarcolemma, ATP-sensitive K+(KATP) channels have more recently also been identified within the inner… (More)
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Highly Cited
1991
Highly Cited
1991
The role of ATP-regulated K+ channels in protecting the myocardium against ischemia/reperfusion damage was explored using… (More)
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Highly Cited
1989
Highly Cited
1989
Vasodilators are used clinically for the treatment of hypertension and heart failure. The effects of some vasodilators seem to be… (More)
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