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Pinacidil

Known as: Guanidine, N''-cyano-N-4-pyridinyl-N'-(1,2,2-trimethylpropylmonohydrate), (+-)-, Pinacidil [Chemical/Ingredient] 
A guanidine that opens POTASSIUM CHANNELS producing direct peripheral vasodilatation of the ARTERIOLES. It reduces BLOOD PRESSURE and peripheral… 
National Institutes of Health

Related topics

Related topics

13 relations

Narrower (2)

3-pyridyl pinacidilPindac

Broader (4)

Antihypertensive AgentsGuanidineMembrane Transport ModulatorsVasodilator Agents
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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2009
2009
Effect of a new vasodilator, pinacidil (P 1134), on potassium, noradrenaline and serotonin induced contractions in rabbit vascular tissues.
Ring preparations of rabbit aorta were contracted by potassium (127 mM). Pinacidil (P 1134), a new vasodilator ( 2.3 x 10(-5) M… 
1999
1999
Differential effects of lidocaine and mexiletine on relaxations to ATP-sensitive K+ channel openers in rat aortas.
BACKGROUND In cardiac myocytes, lidocaine reduces but mexiletine increases adenosine triphosphate (ATP)-sensitive K+ currents… 
1993
1993
Effect of Activation of ATP‐Dependent Potassium Channels with (‐)‐Pinacidil and (‐)‐3‐Pyridyl Pinacidil on Infarct Size in a Canine Model of Ischemia‐Reperfusion Injury
We tested the hypothesis that opening myocardial ATP-dependent K + (ATP-K) channels by administration of (-)-pinacidil or (-)-3… 
1989
1989
Effects of Pinacidil on Myocardial Blood Flow and Infarct Size After Acute Left Anterior Descending Coronary Artery Occlusion and Reperfusion in Awake Dogs With and Without a Coexisting Left…
Summary: To determine whether partial stenosis of a second major coronary artery promoted vasodilator-induced coronary steal and… 
1986
1986
Acute haemodynamic effects of pinacidil in man.
The acute haemodynamic effects of i.v. pinacidil 0.2 mg kg-1 infused over 8 min were studied in 10 normotensive patients… 
1986
1986
Aggressive long-term antihypertensive therapy with pinacidil does not cause regression of cardiovascular hypertrophy in the spontaneously hypertensive rat.
After dosage titration from the age of 1 month to the age of 3 months, spontaneously hypertensive rats (SHR) were treated with… 
1986
1986
Cardiovascular Effects of Pinacidil and Propranolol Alone and in Combination in Normal Humans
Summary: The effects of a long-acting formulation of pinacidil (P1134), a new arteriolar vasodilator, have been investigated in… 
1986
1986
Effects of pinacidil on renal hemodynamics and function in anesthetized dogs.
We studied the effects of pinacidil on renal hemodynamics and function in anesthetized dogs. An intravenous injection of… 
1983
1983
Preliminary evaluation of pinacidil in hypertension.
In a balanced single-blind placebo controlled study in six hypertensive patients treated with diuretic and beta-adrenoceptor… 
1983
1983
Hemodynamic characterization of pinacidil in rats. Comparison with hydralazine.
Pinacidil (N"-cyano-N-4-pyridyl-N'-1,2,2-trimethylpropylguanidine monohydrate; P1134) is a new vasodilator drug with a direct…