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Alpha-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy.
TLDR
ACTC is the first sarcomeric gene described in which mutations are responsible for 2 different cardiomyopathies, and it is hypothesize that ACTC mutations affecting sarcomere contraction lead to FHC and that mutations affecting force transmission from the sar Comere to the surrounding syncytium lead to IDC. Expand
α-cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy
TLDR
The alpha-cardiac actin gene (ACTC) is identified as a novel disease gene in a pedigree suffering from familial hypertrophic cardiomyopathy (FHC), and linkage analyses of plausible candidate genes highly expressed in the adult human heart identified ACTC as the most likely disease gene. Expand
Myocardial structure as a determinant of pre- and postoperative ventricular function and long-term prognosis after valve replacement for aortic stenosis.
TLDR
Abnormalities of the hypertrophied left ventricular muscle cell and the degree of muscle hypertrophy are, to some degree, underlying determinants of pre-operative symptomatology, pre- and postoperative ventricular function, and early and late mortality after valve replacement for aortic stenosis. Expand
Active, passive and myogenic characteristics of isolated rat intramural coronary resistance arteries
TLDR
The smaller active tension of the coronary vessels could not therefore be ascribed to a reduced smooth muscle content, but possibly in part to an observed heterogeneous arrangement of the smooth muscle cells in the coronary Vessels. Expand
2011 consensus statement on endomyocardial biopsy from the Association for European Cardiovascular Pathology and the Society for Cardiovascular Pathology.
TLDR
Determining appropriate EMB use in the context of current diagnostic strategies for cardiac diseases and providing recommendations for its rational utilization and providing standard criteria and guidance for appropriate tissue triage and pathological analysis is suggested. Expand
Evaluation of myocardial iron by magnetic resonance imaging during iron chelation therapy with deferrioxamine: indication of close relation between myocardial iron content and chelatable iron pool.
TLDR
The preliminary data suggest the existence of a critical liver iron concentration above which elevated myocardial iron is present, but its extent seems related to the size of the chelatable iron pool, as reflected by the urinary iron excretion, which supports the concept of the labile iron pool as the compartment directly involved in transfusional iron toxicity. Expand
An increase in sudden unexpected cardiac deaths among young Swedish orienteers during 1979-1992.
TLDR
Histopathological evaluation showed myocarditis in a higher than expected proportion of cases and male Swedish orienteers do not, however, seem to have an increased rate of exposure to this agent. Expand
Prevalence of the parvovirus B19 genome in endomyocardial biopsy specimens.
TLDR
An association of the PVB19 genome in endomyocardial biopsy specimens of adults with the development of DCM, DCMi, and chronic myocarditis more frequently than previously expected is suggested. Expand
The presence of bacteria varies between colorectal adenocarcinomas, precursor lesions and non-malignant tissue
TLDR
Findings do not support a role of F. nucleatum or B. fragilis during colorectal beginning, while a potential role of the bacterial genera Prevotella and Acinetobacter was indicated, and requires further investigations. Expand
Comparison of Human Adipose-Derived Stem cells and Bone Marrow-Derived Stem cells in a Myocardial Infarction Model
TLDR
Neither of the stem cell types induced myocardial angiogenesis, raising the question whether donor age and health have an effect on the efficacy of stem cells used in the treatment of MI. Expand
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