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Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions
TLDR
A considerable body of experimental evidence suggests that L-carnitine exert a protective effect in in vitro and in vivo models of heart ischemia and hypertrophy, and clinical trials confirm these beneficial effects although controversial results are observed.
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Culture of dorsal root ganglion neurons from aged rats: Effects of acetyl-l-carnitine and NGF
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Carnitine protects mitochondria and removes toxic acyls from xenobiotics.
TLDR
The study of peroxisomal producing agents belonging to largely different chemical classes showed that these agents caused carnitine system perturbations which may have the potential to be highly relevant biomarkers of exposure to the nongenotoxic peroxISomal proliferating agent class of hepatic tumorigens.
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The effect of L-carnitine and acetyl-L-carnitine on the disappearance of DNA single-strand breaks in human peripheral blood lymphocytes.
TLDR
It is suggested that treatment with L-carnitine accelerates the disappearance of SSBs induced by oxygen radicals and alkylating agents.
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Sites of action of carnitine and its derivatives on the cardiovascular system: interactions with membranes.
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Evidence for the Involvement of Carnitine‐Dependent Long‐Chain Acyltransferases in Neuronal Triglyceride and Phospholipid Fatty Acid Turnover
TLDR
The results suggest that CRT may be an important partner in the pathway of phospholipid and triglyceride fatty acid turnover in neurons.
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Neural Dysfunction and Metabolic Imbalances in Diabetic Rats: Prevention by Acetyl-L-Carnitine
TLDR
Observations demonstrate a link between imbalances in carnitine metabolism and several metabolic and functional abnormalities associated with diabetic polyneuropathy and indicate that decreased sciatic nerve endoneurial ATPase activity in this model of diabetes is associated with decreased DAG.
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Protective actions of L-carnitine and acetyl-L-carnitine on the neurotoxicity evoked by mitochondrial uncoupling or inhibitors.
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Uncoupling effect of fatty acids on heart muscle mitochondria and submitochondrial particles
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Pertussis vaccine pleurisy: A model of delayed hypersensitivity
TLDR
Male Wistar rats have been sensitized to Bordetella pertussis using a mixture of Freund's incomplete adjuvant and pertussi organisms, and a long period of dosing with either drug, or treatment with indomethacin, suppressed the response.
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