FAQ

Pimelic Acids

Known as: Acids, Pimelic, Pimelic Acids [Chemical/Ingredient] 
A group of compounds that are derivatives of heptanedioic acid with the general formula R-C7H11O4.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1941-2016
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11 relations

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GM 53Pimelic Acidalpha-aminopimelic acidpimelautide
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In Bloodagonistsantagonists & inhibitorschemical synthesis
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Pimelic Acids
In Blood
chemical synthesis
standards characteristics
Pimelic Acid
antagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Correction: Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6/2 and N171-82Q Mouse Models of Huntington’s Disease
This report represents a detailed description of experiments designed to replicate and extend the findings of a published study… (More)
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2012
2012
Oral Administration of the Pimelic Diphenylamide HDAC Inhibitor HDACi 4b Is Unsuitable for Chronic Inhibition of HDAC Activity in the CNS In Vivo
Histone deacetylase (HDAC) inhibitors have received considerable attention as potential therapeutics for a variety of cancers and… (More)
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2011
2011
Prolonged treatment with pimelic o-aminobenzamide HDAC inhibitors ameliorates the disease phenotype of a Friedreich ataxia mouse model
Friedreich ataxia (FRDA) is an inherited neurodegenerative disorder caused by GAA repeat expansion within the FXN gene, leading… (More)
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Highly Cited
2010
Highly Cited
2010
Two New Pimelic Diphenylamide HDAC Inhibitors Induce Sustained Frataxin Upregulation in Cells from Friedreich's Ataxia Patients and in a Mouse Model
BACKGROUND Friedreich's ataxia (FRDA), the most common recessive ataxia in Caucasians, is due to severely reduced levels of… (More)
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Highly Cited
2008
Highly Cited
2008
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I histone deacetylases.
Histone deacetylase (HDAC) inhibitors, including various benzamides and hydroxamates, are currently in clinical development for a… (More)
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Highly Cited
2008
Highly Cited
2008
The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice.
Transcriptional dysregulation has emerged as a core pathologic feature of Huntington's disease (HD), one of several triplet… (More)
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2008
2008
Low-energy collision-induced fragmentation of negative ions derived from diesters of aliphatic dicarboxylic acids made with hydroxybenzoic acids.
Diesters of ortho-hydroxybenzoic acid (salicylic acid) made with glutaric, adipic, and pimelic acids are the monomers of some… (More)
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2005
2005
X-ray studies on crystalline complexes involving amino acids and peptides. XLII. Adipic acid complexes of L- and DL-arginine and supramolecular association in arginine-dicarboxylic acid complexes.
The adipic acid complexes of DL-arginine and L-arginine are made up of zwitterionic, singularly positively charged arginium ions… (More)
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1992
1992
Azelaic and pimelic acids: Metabolic intermediates or artefacts?
Azelaic and pimelic acids are excreted in elevated amounts in urine in disorders of mitochondrial β-oxidation and disorders of… (More)
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1988
1988
Formation of a biotin precursor, pimelic acid, in yeasts from C18 fatty acids.
The biosynthesis of biotin-vitamers from C18 fatty acids in the resting cell reaction system of yeasts was investigated. The… (More)
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