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Protein translation in Plasmodium parasites.
TLDR
What is known about cytosolic and organellar translation in Plasmodium is reviewed and the molecules that have been identified through genome sequencing and post-genomic analysis are discussed. Expand
DOR/Tp53inp2 and Tp53inp1 Constitute a Metazoan Gene Family Encoding Dual Regulators of Autophagy and Transcription
Human DOR/TP53INP2 displays a unique bifunctional role as a modulator of autophagy and gene transcription. However, the domains or regions of DOR that participate in those functions have not beenExpand
Multifunctional nanovesicle-bioactive conjugates prepared by a one-step scalable method using CO2-expanded solvents.
TLDR
A simple one-step methodology based on the use of CO2-expanded solvents to prepare multifunctional nanovesicle-bioactive conjugates that is readily amenable to the integration/encapsulation of multiple components into the nanovesicles in a single step and yields sufficient quantities for clinical research. Expand
Peptide and amide bond-containing dendrimers.
TLDR
Dendrimer Synthesis: Types I and II: Covalent Peptide Dendrimers Based on Amino Acids as Building Blocks 1668 3.1. Expand
Adenosine A2A receptor-antagonist/dopamine D2 receptor-agonist bivalent ligands as pharmacological tools to detect A2A-D2 receptor heteromers.
TLDR
The cooperative effect derived from the simultaneous interaction suggests the occurrence of A(2A)R-D(2)R heteromers in cotransfected cells and in brain striatum, suggesting the dopamine/adenosine bivalent action could constitute a novel concept in Parkinson's disease pharmacotherapy. Expand
Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo
TLDR
It is found that some analogs effectively lose their toxicity against human cells while retaining a potent antiparasitic activity both in vitro and in vivo and cleared malaria from Plasmodium yoelii-infected mice, resulting in 100% mice survival rates. Expand
Injectable Hyaluronan Hydrogels with Peptide-Binding Dendrimers Modulate the Controlled Release of BMP-2 and TGF-β1.
TLDR
The potential of affinity binding peptide functionalized dendrimers to modulate the local delivery and availability of growth factors important for musculoskeletal regeneration therapies is illustrated. Expand
Structure–Activity Relationships of SSAO/VAP‐1 Arylalkylamine‐Based Substrates
TLDR
This review highlights the importance of studying the relevant steric and electronic features in the development of new ligands with better SSAO/VAP‐1 recognition, enhanced selectivity over other amine oxidases, and improved metabolic behavior. Expand
Addressing the Tertiary Structure of Human Parathyroid Hormone-(1–34)*
TLDR
Examining the structure of human PTH-(1–34) under conditions that encompass the different environments the hormone may experience in the approach to and interaction with the G-protein-coupled receptor, there is no evidence for a U-shape conformation or any tertiary structure. Expand
Conformational characterization of a peptide mimetic of the third cytoplasmic loop of the G‐protein coupled parathyroid hormone/parathyroid hormone related protein receptor
TLDR
The conformation and relative orientation of the peptide provided insight into the mechanism by which the cytoplasmic portion of the receptor activates the heterotrimeric, guanine nucleotide‐binding regulatory protein, one of the first steps in signal transduction. Expand
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