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Liquid chromatography/mass spectrometry analysis of mixtures of rhamnolipids produced by Pseudomonas aeruginosa strain 57RP grown on mannitol or naphthalene.
TLDR
Liquid chromatography/mass spectrometry using electrospray ionisation was used to analyse rhamnolipids produced by a Pseudomonas aeruginosa strain with mannitol or naphthalene as carbon source, finding the most abundant rhamNolipid produced from naphtha contained two rham noses and one 3-hydroxydecanoic acid group.
AMPK is a negative regulator of the Warburg effect and suppresses tumor growth in vivo.
TLDR
It is shown that AMPK negatively regulates aerobic glycolysis (the Warburg effect) in cancer cells and suppresses tumor growth in vivo, and that its loss fosters tumor progression in part by regulating cellular metabolic pathways that support cell growth and proliferation.
Coherent heterodyne time-domain spectrometry covering the entire “terahertz gap”
Terahertz waves, electromagnetic radiation in the spectral region commonly defined between 0.3 and 10THz, allow innovative sensing and imaging techniques that can provide spectroscopic information
Loss of the tumor suppressor LKB1 promotes metabolic reprogramming of cancer cells via HIF-1α
TLDR
It is demonstrated here that loss of L KB1 expression in cancer cells promotes a progrowth metabolic profile that enables increased cell growth and proliferation, and implicates the tumor suppressor LKB1 as a central regulator of tumor metabolism and growth control through the regulation of HIF-1α–dependent metabolic reprogramming.
Maple syrup urine disease: Interrelations between branched-chain amino-, oxo- and hydroxyacids; implications for treatment; associations with CNS dysmyelination
TLDR
A relaxed treatment protocol for patients with maple syrup urine disease may benefit them in quality of life, but it apparently exacts a cost in metabolic control and CNS pathology.
The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis
TLDR
It is shown that succinate accumulates in the hypoxic retina of rodents and, via its cognate receptor G protein–coupled receptor-91 (GPR91), is a potent mediator of vessel growth in the settings of both normal retinal development and proliferative ischemic retinopathy.
On the mechanisms of the formation of L-alloisoleucine and the 2-hydroxy-3-methylvaleric acid stereoisomers from L-isoleucine in maple syrup urine disease patients and in normal humans.
TLDR
Evidence presented here suggests that racemization of the 3-carbon of L-isoleucine occurs during transamination, that L-alloisoleucines is an inherently unavoidable by-product of L/S-KMVA transamination (and vice versa), and that a KMVA enol is not obligate in this racemized.
Hereditary and acquired diseases of acyl-coenzyme A metabolism.
TLDR
Acyl-CoA metabolism is reviewed, including CoASH synthesis, transesterification of acyl- CoAs to glycine, glutamate or l-carnitine and hydrolysis of CoA esters, which is a major source of intracellular toxicity in CASTOR diseases.
Glutathione deficiency as a complication of methylmalonic acidemia: response to high doses of ascorbate.
TLDR
A 7-year-old boy with deficient activity of methylmalonyl coenzyme A mutase (mut-methylmalonic acidemia) was seen in severe metabolic crisis and high-dose ascorbate therapy (120 mg/kg) commenced.
Plasma kinetics of VLDL and HDL apoC-I in normolipidemic and hypertriglyceridemic subjects DOI 10.1194/jlr.M200055-JLR200
TLDR
It is demonstrated that increased levels of plasma and VLDL apoC-I in hypertriglyceridemic subjects (with or without elevated LDL-C levels) are associated with increased levels with increased rates of plasma VLDl apo C-I production.
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