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Pilocarpine

Known as: 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-, (3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone, (3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone 
A natural alkaloid extracted from plants of the genus Pilocarpus with cholinergic agonist activity. As a cholinergic parasympathomimetic agent… 
National Institutes of Health

Related topics

Related topics

36 relations

Narrower (11)

3-hydroxypilocarpineBetoptic PiloGlauko-BicironIsoptocarpine

Broader (5)

AlkaloidsCholinergic AgentsGanglionic StimulantsMiotics
Angle Closure GlaucomaAsthmaDrug AllergyHead and Neck Neoplasms

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Do Seizures in the Pilocarpine Model Start in the Hippocampal Formation?
Commentary Temporal lobe epilepsy is common and often is difficult to treat, making this focal epilepsy a major challenge for… 
Highly Cited
2013
Highly Cited
2013
O Brother, Wherefore Are Thou? Calcium-Permeable AMPA Receptors Make an Appearance in Adult Status Epilepticus
Commentary The α-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)-type glutamate receptors (AMPAR) are normally assembled… 
Highly Cited
2012
Highly Cited
2012
Interleukin‐1β and microRNA‐146a in an immature rat model and children with mesial temporal lobe epilepsy
Purpose:  Increasing evidence indicates that neuroinflammation plays a critical role in the pathogenesis of mesial temporal lobe… 
Highly Cited
2007
Highly Cited
2007
Pilocarpine-Induced Seizures Cause Selective Time-Dependent Changes to Adult-Generated Hippocampal Dentate Granule Cells
Aberrantly interconnected granule cells are characteristic of temporal lobe epilepsy. By reducing network stability, these… 
Highly Cited
2005
Highly Cited
2005
Drug release and permeation studies of nanosuspensions based on solidified reverse micellar solutions (SRMS).
Highly Cited
2003
Highly Cited
2003
Measurement of accommodation after implantation of an accommodating posterior chamber intraocular lens
Highly Cited
1996
Highly Cited
1996
Nicotinic, muscarinic and dopaminergic actions in the ventral hippocampus and the nucleus accumbens: effects on spatial working memory in rats
Highly Cited
1994
Highly Cited
1994
Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents
Highly Cited
1994
Highly Cited
1994
The competitive NMDA receptor antagonist CGP 40116 protects against status epilepticus-induced neuronal damage
Highly Cited
1962
Highly Cited
1962
Salivary gland changes after isoproterenol-induced enlargement.
Salivary glands and cardiac ventricles were examined after chronic administration of pharmacological doses of isoproterenol (ISO… 
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