Pilocarpine

Known as: 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-, (3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone, (3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone 
A natural alkaloid extracted from plants of the genus Pilocarpus with cholinergic agonist activity. As a cholinergic parasympathomimetic agent… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1935-2018
010020019352017

Papers overview

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Highly Cited
2006
Highly Cited
2006
Recent evidences suggest key roles of abnormal neurogenesis and astrogliosis in the pathogenesis of epilepsy. Alterations in the… (More)
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Highly Cited
2003
Highly Cited
2003
The rodent pilocarpine model of epilepsy exhibits hippocampal sclerosis and spontaneous seizures and thus resembles human… (More)
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Highly Cited
1997
Highly Cited
1997
The dentate granule cell layer of the rodent hippocampal formation has the distinctive property of ongoing neurogenesis that… (More)
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Highly Cited
1993
Highly Cited
1993
We used the pilocarpine model of chronic spontaneous recurrent seizures to evaluate the time course of supragranular dentate… (More)
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Highly Cited
1993
Highly Cited
1993
BACKGROUND AND METHODS We evaluated pilocarpine hydrochloride for the treatment of radiation-induced xerostomia, a common… (More)
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Highly Cited
1991
Highly Cited
1991
Structural damage of the human brain (perinatal damage, cerebral trauma, head injury, cerebrovascular and degenerative diseases… (More)
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Highly Cited
1987
Highly Cited
1987
Subcutaneous treatment of rats with low doses of lithium and pilocarpine or a high dose of pilocarpine results in a severe… (More)
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Highly Cited
1986
Highly Cited
1986
Using an unobtrusive eyedrop medication monitor, we measured compliance with topical pilocarpine treatment in a sample of 184… (More)
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Highly Cited
1984
Highly Cited
1984
Increasing doses of pilocarpine, 100-400 mg/kg, were given intraperitoneally to mice and the resulting behavioral… (More)
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Highly Cited
1983
Highly Cited
1983
Behavioural, electroencephalographic and neuropathological responses to increasing doses of pilocarpine (100-400 mg/kg… (More)
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