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Pilocarpine

Known as: 2(3H)-Furanone, 3-ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-, (3S-cis)-, (3S,4R)-3-Ethyldihydro-4-((1-methyl-1H-imidazol-5-yl)methyl)-2(3H)-furanone, (3S-cis)-3-Ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)methyl]-2(3H)-furanone 
A natural alkaloid extracted from plants of the genus Pilocarpus with cholinergic agonist activity. As a cholinergic parasympathomimetic agent… 
National Institutes of Health

Related topics

Related topics

36 relations

Narrower (11)

3-hydroxypilocarpineBetoptic PiloGlauko-BicironIsoptocarpine

Broader (5)

AlkaloidsCholinergic AgentsGanglionic StimulantsMiotics
Angle Closure GlaucomaAsthmaDrug AllergyHead and Neck Neoplasms

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
Salivary dysfunction associated with systemic diseases: systematic review and clinical management recommendations.
Review
1995
Review
1995
The pilocarpine model of epilepsy
The systemic administration of a potent muscarinic agonist pilocarpine in rats promotes sequential behavioural and electrographic… 
Review
1995
Review
1995
Microspheres and nanoparticles used in ocular delivery systems
Highly Cited
1993
Highly Cited
1993
Circuit Mechanisms of Seizures in the Pilocarpine Model of Chronic Epilepsy: Cell Loss and Mossy Fiber Sprouting
We used the pilocarpine model of chronic spontaneous recurrent seizures to evaluate the time course of supragranular dentate… 
Highly Cited
1993
Highly Cited
1993
Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures
In situ hybridization methods were used to determine if glutamic acid decarboxylase (GAD) mRNA-containing neurons within the… 
Highly Cited
1991
Highly Cited
1991
Long‐Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures
Summary: Structural damage of the human brain (perinatal damage, cerebral trauma, head injury, cerebrovascular and degenerative… 
Review
1990
Review
1990
A progressive sequence of electroencephalographic changes during generalized convulsive status epilepticus
Review
1989
Review
1989
Animal models of the epilepsies
Highly Cited
1979
Highly Cited
1979
Mechanistic and quantitative evaluation of precorneal pilocarpine disposition in albino rabbits.
The low ocular bioavailability of topically applied pilocarpine is attributed to extensive precorneal drug loss in conjection… 
Highly Cited
1972
Highly Cited
1972
Three acetylcholine receptors in Aplysia neurones
1. In the pleural ganglion of Aplysia californica, groups of cells were identified that respond differently to an iontophoretic… 
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