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Matrix metalloproteinases and their inhibitors in aqueous humor of patients with pseudoexfoliation syndrome/glaucoma and primary open-angle glaucoma.
TLDR
The findings suggest that complex changes in the local MMP-TIMP balance and reduced MMP activity in aqueous humor may promote the abnormal matrix accumulation characteristic of PEX syndrome and may be causally involved in the pathogenesis of both PEX glaucoma and POAG.
Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin.
TLDR
Immunohistochemistry with novel lymph-endothelium markers and ultrastructural analyses indicate the existence of lymphatic vessels in vascularized human corneas, which appears to be correlated with the degree of corneal hemangiogenesis and may be mediated by VEGF-C and its receptor VEGFR3.
Role of transforming growth factor-beta1 and its latent form binding protein in pseudoexfoliation syndrome.
TLDR
Increased levels of latent and active TGF-beta1 in the aqueous humor of PEX patients, derived from enhanced local synthesis and activation, promote the buildup of the abnormal extracellular elastic material characteristic of P EX syndrome.
Reevaluation of Corneal Dystrophies of Bowman's Layer and the Anterior Stroma (Reis-Bücklers and Thiel-Behnke Types): A Light and Electron Microscopic Study of Eight Corneas and a Review of the
TLDR
It is concluded that two distinct autosomal dominant CDB exist and proposed the designations CDB type I (synonyms: geographic or “true” Reis-Biicklers' dystrophy) andCDB type II ( synonyms: honeycomb-shaped or Thiel-Behnke's dystropy).
Pericyte recruitment in human corneal angiogenesis: an ultrastructural study with clinicopathological correlation
TLDR
Therapeutic strategies aimed at regression of immature, not yet pericyte covered vessels by antagonising angiogenic factors should be most effective if applied very early in the course of corneal neovascularisation.
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