FAQ

Phosphatidylinositol 4,5-Diphosphate

Known as: Phosphatidylinositol-4,5-Biphosphate, PtsIns-4,5-P2, 4,5-Biphosphate, Phosphatidylinositol 
A phospholipid that is a component of the plasma membrane with signal transduction inducing activity. Phosphatidylinositol 4,5-bisphosphate (PIP2) is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2018
05010015019762018

Related topics

Related topics

14 relations
In BloodProcess of secretionagonistsanalogs & derivatives
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Broader (1)

Phosphatidylinositol Phosphates

Narrower (3)

dioctanoyl-phosphatidylinositol 4,5-bisphosphatephosphatidylinositol-3,4,5-trisphosphorothioatephosphatidylinositol-4,5-bisphosphate hydrolysis

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Phosphatidylinositol 4,5-Diphosphate
physiological aspects
In Blood
chemical synthesis
Phosphatidylinositol Phosphates
standards characteristics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
PTEN-Mediated Apical Segregation of Phosphoinositides Controls Epithelial Morphogenesis through Cdc42
Formation of the apical surface and lumen is a fundamental, yet poorly understood, step in epithelial organ development. We show… (More)
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Highly Cited
2006
Highly Cited
2006
Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling
Toll-like receptors (TLRs) play a critical role in the immune system as sensors of microbial infection. Signaling downstream from… (More)
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Highly Cited
2001
Highly Cited
2001
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
Tissue injury generates endogenous factors that heighten our sense of pain by increasing the response of sensory nerve endings to… (More)
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Highly Cited
2001
Highly Cited
2001
Simultaneous binding of PtdIns(4,5)P2 and clathrin by AP180 in the nucleation of clathrin lattices on membranes.
Adaptor protein 180 (AP180) and its homolog, clathrin assembly lymphoid myeloid leukemia protein (CALM), are closely related… (More)
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Highly Cited
1999
Highly Cited
1999
Rac Homologues and Compartmentalized Phosphatidylinositol 4, 5-Bisphosphate Act in a Common Pathway to Regulate Polar Pollen Tube Growth
Pollen tube cells elongate based on actin- dependent targeted secretion at the tip. Rho family small GTPases have been implicated… (More)
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Highly Cited
1998
Highly Cited
1998
Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gβγ
Inward rectifier K+ channels, which modulate electrical activity in many cell types, are regulated by protein kinases,, guanine… (More)
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Highly Cited
1998
Highly Cited
1998
Receptor-induced transient reduction in plasma membrane PtdIns(4,5)P2 concentration monitored in living cells
Although phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) is a well-characterized precursor for the second messengers… (More)
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Highly Cited
1996
Highly Cited
1996
N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases.
Here we identify a 65 kDa protein (N-WASP) from brain that binds the SH3 domains of Ash/Grb2. The sequence is homologous to… (More)
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Highly Cited
1993
Highly Cited
1993
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.
Phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of neutrophils to the chemoattractant N… (More)
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Highly Cited
1983
Highly Cited
1983
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
Activation of receptors for a wide variety of hormones and neurotransmitters leads to an increase in the intracellular level of… (More)
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