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Phosphatidylinositol 4,5-Diphosphate

Known as: Phosphatidylinositol-4,5-Biphosphate, PtsIns-4,5-P2, 4,5-Biphosphate, Phosphatidylinositol 
A phospholipid that is a component of the plasma membrane with signal transduction inducing activity. Phosphatidylinositol 4,5-bisphosphate (PIP2) is… 
National Institutes of Health

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14 relations
In BloodProcess of secretionagonistsanalogs & derivatives

Broader (1)

Phosphatidylinositol Phosphates

Narrower (3)

dioctanoyl-phosphatidylinositol 4,5-bisphosphatephosphatidylinositol-3,4,5-trisphosphorothioatephosphatidylinositol-4,5-bisphosphate hydrolysis

Papers overview

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1989
1989
Membrane anchors of alkaline phosphatase and trehalase associated with the plasma membrane of larval midgut epithelial cells of the silkworm, Bombyx mori.
The larval midgut epithelial cell of the silkworm, Bombyx mori, has two forms of alkaline phosphatase and trehalase, soluble and… 
1987
1987
Phorbol esters and dioctanoylglycerol block anti-IgM-stimulated phosphoinositide hydrolysis in the murine B cell lymphoma WEHI-231.
Cross-linking of membrane IgM (mIgM) on both normal resting B cells and on the murine B cell lymphoma WEHI-231 activates the… 
1986
1986
Activation of muscarinic receptors in PC12 cells. Correlation between cytosolic Ca2+ rise and phosphoinositide hydrolysis.
The intracellular signals generated by carbachol activation of the muscarinic receptor [release of inositol phosphates as a… 
Highly Cited
1986
Highly Cited
1986
BSF1 induces membrane protein phosphorylation but not phosphoinositide metabolism, Ca2+ mobilization, protein kinase C translocation, or membrane depolarization in resting murine B lymphocytes.
The findings presented in this study provide evidence that BSF1 receptors and mIg transmit signals via dissimilar transduction… 
1986
1986
Inositol cyclic triphosphate [inositol 1,2-(cyclic)-4,5-triphosphate] is formed upon thrombin stimulation of human platelets.
Cleavage of polyphosphoinositides in vitro by phospholipase C results in formation of both cyclic and noncyclic inositol… 
1986
1986
The decrease in phosphatidylinositol 4,5-bisphosphate in ADP-stimulated washed rabbit platelets is not primarily due to phospholipase C activation.
Addition of 10 micron-ADP to washed rabbit platelets caused platelet shape change and aggregation without release of the contents… 
Highly Cited
1985
Highly Cited
1985
Dependence on Ca2+ of the activities of phosphatidylinositol 4,5-bisphosphate phosphodiesterase and inositol 1,4,5-trisphosphate phosphatase in smooth muscles of the porcine coronary artery.
The activities of phosphatidylinositol 4,5-bisphosphate (PIP2) phosphodiesterase (PDE) and inositol 1,4,5,-trisphosphate (IP3… 
1985
1985
Cyclosporine does not inhibit mitogen-induced inositol phospholipid degradation in mouse lymphocytes.
The degradation of phosphatidylinositol bisphosphate (PIP2) to diacylglycerol and inositol trisphosphate is elicited by ligand… 
Highly Cited
1984
Highly Cited
1984
Nutrient and hormone-neurotransmitter stimuli induce hydrolysis of polyphosphoinositides in rat pancreatic islets.
Preincubation of rat pancreatic islets with 3H-inositol, and subsequent exposure, in the presence of LiCl, to either glucose or… 
1984
1984
Changes in the platelet phosphoinositides during the first minute after stimulation of washed rabbit platelets with thrombin.
Experiments with washed platelets from rabbits demonstrate that stimulation with a low concentration of thrombin (0.1 unit/ml…