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Phosphatidylinositol 4,5-Diphosphate

Known as: Phosphatidylinositol-4,5-Biphosphate, PtsIns-4,5-P2, 4,5-Biphosphate, Phosphatidylinositol 
A phospholipid that is a component of the plasma membrane with signal transduction inducing activity. Phosphatidylinositol 4,5-bisphosphate (PIP2) is… Expand
National Institutes of Health

Related topics

Related topics

14 relations
In BloodProcess of secretionagonistsanalogs & derivatives
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Broader (1)

Phosphatidylinositol Phosphates

Narrower (3)

dioctanoyl-phosphatidylinositol 4,5-bisphosphatephosphatidylinositol-3,4,5-trisphosphorothioatephosphatidylinositol-4,5-bisphosphate hydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Targeting PI3K in cancer: mechanisms and advances in clinical trials
Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) signaling is one of the most important… Expand
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Highly Cited
2016
Highly Cited
2016
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When… Expand
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Highly Cited
2003
Highly Cited
2003
Membrane cholesterol, lateral mobility, and the phosphatidylinositol 4,5-bisphosphate-dependent organization of cell actin
Responses to cholesterol depletion are often taken as evidence of a role for lipid rafts in cell function. Here, we show that… Expand
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Highly Cited
2001
Highly Cited
2001
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
Tissue injury generates endogenous factors that heighten our sense of pain by increasing the response of sensory nerve endings to… Expand
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Highly Cited
2001
Highly Cited
2001
Nck and Phosphatidylinositol 4,5-Bisphosphate Synergistically Activate Actin Polymerization through the N-WASP-Arp2/3 Pathway*
The Wiskott-Aldrich syndrome protein (WASP) and its relative neural WASP (N-WASP) regulate the nucleation of actin filaments… Expand
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Highly Cited
2000
Highly Cited
2000
Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton–Plasma Membrane Adhesion
Binding interactions between the plasma membrane and the cytoskeleton define cell functions such as cell shape, formation of cell… Expand
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Highly Cited
2000
Highly Cited
2000
Mechanism of N-Wasp Activation by Cdc42 and Phosphatidylinositol 4,5-Bisphosphate
Neuronal Wiskott-Aldrich Syndrome protein (N-WASP) transmits signals from Cdc42 to the nucleation of actin filaments by Arp2/3… Expand
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Highly Cited
2000
Highly Cited
2000
Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3
BACKGROUND Phosphatidylinositol 4,5-bisphosphate (PIP(2)) has been implicated in the regulation of the actin cytoskeleton and… Expand
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Highly Cited
1996
Highly Cited
1996
Premature Infant Pain Profile: development and initial validation.
OBJECTIVE Inadequate assessment of pain in premature infants is a persistent clinical problem. The objective of this research was… Expand
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Highly Cited
1985
Highly Cited
1985
Specific interaction between phosphatidylinositol 4,5-bisphosphate and profilactin
There is evidence that the polymerization of actin takes place at the plasma membrane1, and that profilactin (profilin/actin… Expand
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