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Phosphatidylinositol 4,5-Diphosphate

Known as: Phosphatidylinositol-4,5-Biphosphate, PtsIns-4,5-P2, 4,5-Biphosphate, Phosphatidylinositol 
A phospholipid that is a component of the plasma membrane with signal transduction inducing activity. Phosphatidylinositol 4,5-bisphosphate (PIP2) is… Expand
National Institutes of Health

Related topics

Related topics

14 relations
In BloodProcess of secretionagonistsanalogs & derivatives
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Broader (1)

Phosphatidylinositol Phosphates

Narrower (3)

dioctanoyl-phosphatidylinositol 4,5-bisphosphatephosphatidylinositol-3,4,5-trisphosphorothioatephosphatidylinositol-4,5-bisphosphate hydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When… Expand
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Highly Cited
2013
Highly Cited
2013
Rapid phosphatidic acid accumulation in response to low temperature stress in Arabidopsis is generated through diacylglycerol kinase
Phosphatidic acid (PtdOH) is emerging as an important signaling lipid in abiotic stress responses in plants. The effect of cold… Expand
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Review
2001
Review
2001
Regulation of phosphoinositide-specific phospholipase C.
  • S. Rhee
  • Annual review of biochemistry
  • 2001
    • Corpus ID: 21158219
Eleven distinct isoforms of phosphoinositide-specific phospholipase C (PLC), which are grouped into four subfamilies (beta, gamma… Expand
Highly Cited
2001
Highly Cited
2001
Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition
Tissue injury generates endogenous factors that heighten our sense of pain by increasing the response of sensory nerve endings to… Expand
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Highly Cited
1996
Highly Cited
1996
Premature Infant Pain Profile: development and initial validation.
OBJECTIVE Inadequate assessment of pain in premature infants is a persistent clinical problem. The objective of this research was… Expand
Highly Cited
1993
Highly Cited
1993
Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.
Phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of neutrophils to the chemoattractant N… Expand
Review
1988
Review
1988
Cell-surface anchoring of proteins via glycosyl-phosphatidylinositol structures.
A class of membrane molecules has been identified whose primary translation product includes a COOH-terminal protein sequence… Expand
Review
1984
Review
1984
Inositol trisphosphate, a novel second messenger in cellular signal transduction
There has recently been rapid progress in understanding receptors that generate intracellular signals from inositol lipids. One… Expand
Highly Cited
1983
Highly Cited
1983
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
Activation of receptors for a wide variety of hormones and neurotransmitters leads to an increase in the intracellular level of… Expand
Highly Cited
1983
Highly Cited
1983
Rapid accumulation of inositol trisphosphate reveals that agonists hydrolyse polyphosphoinositides instead of phosphatidylinositol.
  • M. Berridge
  • The Biochemical journal
  • 1983
    • Corpus ID: 36936318
The agonist-dependent hydrolysis of inositol phospholipids was investigated by studying the breakdown of prelabelled lipid or by… Expand
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