Phosphatidylinositol 4,5-Diphosphate

Known as: Phosphatidylinositol-4,5-Biphosphate, PtsIns-4,5-P2, 4,5-Biphosphate, Phosphatidylinositol 
A phospholipid that is a component of the plasma membrane with signal transduction inducing activity. Phosphatidylinositol 4,5-bisphosphate (PIP2) is… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2018
05010015019762018

Papers overview

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Highly Cited
2007
Highly Cited
2007
Formation of the apical surface and lumen is a fundamental, yet poorly understood, step in epithelial organ development. We show… (More)
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Highly Cited
2006
Highly Cited
2006
Toll-like receptors (TLRs) play a critical role in the immune system as sensors of microbial infection. Signaling downstream from… (More)
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Highly Cited
2001
Highly Cited
2001
Tissue injury generates endogenous factors that heighten our sense of pain by increasing the response of sensory nerve endings to… (More)
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Highly Cited
2001
Highly Cited
2001
Adaptor protein 180 (AP180) and its homolog, clathrin assembly lymphoid myeloid leukemia protein (CALM), are closely related… (More)
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Highly Cited
1999
Highly Cited
1999
Pollen tube cells elongate based on actin- dependent targeted secretion at the tip. Rho family small GTPases have been implicated… (More)
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Highly Cited
1998
Highly Cited
1998
Inward rectifier K+ channels, which modulate electrical activity in many cell types, are regulated by protein kinases,, guanine… (More)
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Highly Cited
1998
Highly Cited
1998
Although phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) is a well-characterized precursor for the second messengers… (More)
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Highly Cited
1996
Highly Cited
1996
Here we identify a 65 kDa protein (N-WASP) from brain that binds the SH3 domains of Ash/Grb2. The sequence is homologous to… (More)
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Highly Cited
1993
Highly Cited
1993
Phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of neutrophils to the chemoattractant N… (More)
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Highly Cited
1983
Highly Cited
1983
Activation of receptors for a wide variety of hormones and neurotransmitters leads to an increase in the intracellular level of… (More)
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