Skip to search formSkip to main contentSkip to account menu

Phosphatidylinositol 4,5-Diphosphate

Known as: Phosphatidylinositol-4,5-Biphosphate, PtsIns-4,5-P2, 4,5-Biphosphate, Phosphatidylinositol 
A phospholipid that is a component of the plasma membrane with signal transduction inducing activity. Phosphatidylinositol 4,5-bisphosphate (PIP2) is… 
National Institutes of Health

Related topics

Related topics

14 relations
In BloodProcess of secretionagonistsanalogs & derivatives

Broader (1)

Phosphatidylinositol Phosphates

Narrower (3)

dioctanoyl-phosphatidylinositol 4,5-bisphosphatephosphatidylinositol-3,4,5-trisphosphorothioatephosphatidylinositol-4,5-bisphosphate hydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1989
Highly Cited
1989
Hormone-evoked calcium release from intracellular stores is a quantal process.
Ca2+ mobilization by hormones, ionomycin, and inositol 1,4,5-trisphosphate (Ins-1,4,5-P3) were studied to determine whether Ca2… 
Highly Cited
1988
Highly Cited
1988
Mitogenesis in response to PDGF and bombesin abolished by microinjection of antibody to PIP2.
The turnover of phosphatidylinositol 4,5-bisphosphate (PIP2) is believed to constitute a crucial step in the signaling pathways… 
Highly Cited
1987
Highly Cited
1987
Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.
Highly Cited
1986
Highly Cited
1986
Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet…
Highly Cited
1986
Highly Cited
1986
Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.
Review
1986
Review
1986
Model for Leukocyte Regulation by Chemoattractant Receptors: Roles of a Guanine Nucleotide Regulatory Protein and Polyphosphoinositide Metabolism
Binding of chemoattractants to their receptors on phagocytes activates a guanine nucleotide regulatory (N) protein through the… 
Highly Cited
1986
Highly Cited
1986
Thyrotropin-releasing hormone and GTP activate inositol trisphosphate formation in membranes isolated from rat pituitary cells.
Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by a phospholipase C to produce inositol… 
Highly Cited
1985
Highly Cited
1985
Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes.
Highly Cited
1982
Highly Cited
1982
Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.
Highly Cited
1981
Highly Cited
1981
The polyphosphoinositide phosphodiesterase of erythrocyte membranes.
1. A new assay procedure has been devised for measurement of the Ca(2+)-activated polyphosphoinositide phosphodiesterase… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)