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Phosphatidylinositol 4,5-Diphosphate
Known as:
Phosphatidylinositol-4,5-Biphosphate
, PtsIns-4,5-P2
, 4,5-Biphosphate, Phosphatidylinositol
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A phospholipid that is a component of the plasma membrane with signal transduction inducing activity. Phosphatidylinositol 4,5-bisphosphate (PIP2) is…
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National Institutes of Health
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Related topics
Related topics
14 relations
In Blood
Process of secretion
agonists
analogs & derivatives
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Broader (1)
Phosphatidylinositol Phosphates
Narrower (3)
dioctanoyl-phosphatidylinositol 4,5-bisphosphate
phosphatidylinositol-3,4,5-trisphosphorothioate
phosphatidylinositol-4,5-bisphosphate hydrolysis
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1989
Highly Cited
1989
Hormone-evoked calcium release from intracellular stores is a quantal process.
Shmuel MuallemSS
,
Stephen J. PandolT
,
Timothy G. BeekerS
Journal of Biological Chemistry
1989
Corpus ID: 18760702
Ca2+ mobilization by hormones, ionomycin, and inositol 1,4,5-trisphosphate (Ins-1,4,5-P3) were studied to determine whether Ca2…
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Highly Cited
1988
Highly Cited
1988
Mitogenesis in response to PDGF and bombesin abolished by microinjection of antibody to PIP2.
K. Matuoka
,
K. Fukami
,
O. Nakanishi
,
S. Kawai
,
T. Takenawa
Science
1988
Corpus ID: 13650693
The turnover of phosphatidylinositol 4,5-bisphosphate (PIP2) is believed to constitute a crucial step in the signaling pathways…
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Highly Cited
1987
Highly Cited
1987
Guanine nucleotides induce Ca2+-independent insulin secretion from permeabilized RINm5F cells.
L. Vallar
,
T. J. Biden
,
C. Wollheim
Journal of Biological Chemistry
1987
Corpus ID: 95036
Highly Cited
1986
Highly Cited
1986
Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet…
L. Brass
,
M. Laposata
,
H. S. Banga
,
S. Rittenhouse
Journal of Biological Chemistry
1986
Corpus ID: 26018237
Highly Cited
1986
Highly Cited
1986
Studies on the hepatic calcium-mobilizing activity of aluminum fluoride and glucagon. Modulation by cAMP and phorbol myristate acetate.
P. Blackmore
,
J. Exton
Journal of Biological Chemistry
1986
Corpus ID: 23756201
Review
1986
Review
1986
Model for Leukocyte Regulation by Chemoattractant Receptors: Roles of a Guanine Nucleotide Regulatory Protein and Polyphosphoinositide Metabolism
R. Snyderman
,
Charles D. Smith
,
M. Verghese
Journal of Leukocyte Biology
1986
Corpus ID: 33233745
Binding of chemoattractants to their receptors on phagocytes activates a guanine nucleotide regulatory (N) protein through the…
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Highly Cited
1986
Highly Cited
1986
Thyrotropin-releasing hormone and GTP activate inositol trisphosphate formation in membranes isolated from rat pituitary cells.
R. Straub
,
M. Gershengorn
Journal of Biological Chemistry
1986
Corpus ID: 36999905
Stimulation of the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) by a phospholipase C to produce inositol…
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Highly Cited
1985
Highly Cited
1985
Potential role for a guanine nucleotide regulatory protein in chemoattractant receptor mediated polyphosphoinositide metabolism, Ca++ mobilization and cellular responses by leukocytes.
M. Verghese
,
C. Smith
,
R. Snyderman
Biochemical and Biophysical Research…
1985
Corpus ID: 35494746
Highly Cited
1982
Highly Cited
1982
Rapid decrease of phosphatidylinositol 4,5-bisphosphate in thrombin-stimulated platelets.
M. Billah
,
E. Lapetina
Journal of Biological Chemistry
1982
Corpus ID: 31074443
Highly Cited
1981
Highly Cited
1981
The polyphosphoinositide phosphodiesterase of erythrocyte membranes.
C. Downes
,
R. H. Michell
Biochemical Journal
1981
Corpus ID: 5709537
1. A new assay procedure has been devised for measurement of the Ca(2+)-activated polyphosphoinositide phosphodiesterase…
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