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Phosphatidylinositol 4,5-Diphosphate

Known as: Phosphatidylinositol-4,5-Biphosphate, PtsIns-4,5-P2, 4,5-Biphosphate, Phosphatidylinositol 
A phospholipid that is a component of the plasma membrane with signal transduction inducing activity. Phosphatidylinositol 4,5-bisphosphate (PIP2) is… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Inflammatory caspases (caspases 1, 4, 5 and 11) are activated in response to microbial infection and danger signals. When… Expand
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Highly Cited
2013
Highly Cited
2013
Phosphatidic acid (PtdOH) is emerging as an important signaling lipid in abiotic stress responses in plants. The effect of cold… Expand
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Review
2001
Review
2001
  • S. Rhee
  • Annual review of biochemistry
  • 2001
  • Corpus ID: 21158219
Eleven distinct isoforms of phosphoinositide-specific phospholipase C (PLC), which are grouped into four subfamilies (beta, gamma… Expand
Highly Cited
2001
Highly Cited
2001
Tissue injury generates endogenous factors that heighten our sense of pain by increasing the response of sensory nerve endings to… Expand
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Highly Cited
1996
Highly Cited
1996
OBJECTIVE Inadequate assessment of pain in premature infants is a persistent clinical problem. The objective of this research was… Expand
Highly Cited
1993
Highly Cited
1993
Phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) is rapidly produced upon exposure of neutrophils to the chemoattractant N… Expand
Review
1988
Review
1988
A class of membrane molecules has been identified whose primary translation product includes a COOH-terminal protein sequence… Expand
Review
1984
Review
1984
There has recently been rapid progress in understanding receptors that generate intracellular signals from inositol lipids. One… Expand
Highly Cited
1983
Highly Cited
1983
Activation of receptors for a wide variety of hormones and neurotransmitters leads to an increase in the intracellular level of… Expand
Highly Cited
1983
Highly Cited
1983
  • M. Berridge
  • The Biochemical journal
  • 1983
  • Corpus ID: 36936318
The agonist-dependent hydrolysis of inositol phospholipids was investigated by studying the breakdown of prelabelled lipid or by… Expand