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CD14-dependent Lipopolysaccharide-induced β-Defensin-2 Expression in Human Tracheobronchial Epithelium*
The induction of host antimicrobial molecules following binding of pathogen components to pattern recognition receptors such as CD14 and the Toll-like receptors (TLRs) is a key feature of innateExpand
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Targeted Disruption of the Leukotriene B4Receptor in Mice Reveals Its Role in Inflammation and Platelet-Activating Factor–Induced Anaphylaxis
Leukotrienes are derived from arachidonic acid and serve as mediators of inflammation and immediate hypersensitivity. Leukotriene B4 (LTB4) and leukotriene C4 (LTC4) act through G protein–coupledExpand
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Regulation of distinct cyclic AMP-specific phosphodiesterase (phosphodiesterase type 4) isozymes in human monocytic cells.
Many functions of the immune and inflammatory responses are inhibited by agents that increase intracellular levels of cAMP. Recent investigations have revealed that cAMP levels in inflammatory cellsExpand
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Regulation of tumour necrosis factor-α processing by a metalloproteinase inhibitor
TUMOUR necrosis factor-αa (TNF-α) is a potent pro-inflammatory agent produced primarily by activated monocytes and macrophages1. TNF-α is synthesized as a precursor protein of Mr 26,000 (26K) whichExpand
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Role of a guanine nucleotide regulatory protein in the activation of phospholipase C by different chemoattractants.
It is well established that formyl peptide chemoattractants can activate a phospholipase C in leukocytes via a pertussis toxin (PT)-sensitive guanine nucleotide regulatory (G) protein. Whether thisExpand
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Cytokine secretion by cystic fibrosis airway epithelial cells.
It is controversial whether mutations in cystic fibrosis transmembrane conductance regulator intrinsically dysregulate inflammation. We characterized passage 2 human tracheobronchial epithelial cellExpand
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  • Open Access
P2U Agonists Induce Chemotaxis and Actin Polymerization in Human Neutrophils and Differentiated HL60 Cells*
Human neutrophils or HL60 cells express P2U receptors and respond to micromolar concentrations of ATP, adenosine 5′-O-(thiotriphosphate) (ATPγS), or UTP with immediate increases in intracellular Ca2+Expand
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Function and regulation of chemoattractant receptors
Phagocyte migration and activation at sites of inflammation is mediated through chemoattractant receptors that are coupled to G-proteins. Early studies from our laboratory demonstratedExpand
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Airway epithelial cell tolerance to Pseudomonas aeruginosa
BackgroundThe respiratory tract epithelium is a critical environmental interface that regulates inflammation. In chronic infectious airway diseases, pathogens may permanently colonize normallyExpand
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Model for Leukocyte Regulation by Chemoattractant Receptors: Roles of a Guanine Nucleotide Regulatory Protein and Polyphosphoinositide Metabolism
Binding of chemoattractants to their receptors on phagocytes activates a guanine nucleotide regulatory (N) protein through the substitution of GTP for GDP on N. The activated N protein in turnExpand
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