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Visualizing Spatiotemporal Dynamics of Multicellular Cell-Cycle Progression
Time-lapse imaging is performed to explore the spatiotemporal patterns of cell-cycle dynamics during the epithelial-mesenchymal transition of cultured cells, the migration and differentiation of neural progenitors in brain slices, and the development of tumors across blood vessels in live mice. Expand
Scale: a chemical approach for fluorescence imaging and reconstruction of transparent mouse brain
In Scale-treated mouse brain, neurons labeled with genetically encoded fluorescent proteins were visualized at an unprecedented depth in millimeter-scale networks and at subcellular resolution, suggesting that the Scale method will be useful for light microscopy–based connectomics of cellular networks in brain and other tissues. Expand
Multiple roles of phosphoinositide-specific phospholipase C isozymes.
The structural organization, enzymatic properties and molecular diversity of PLC splicing variants are discussed and functional and physiological roles of each isozyme are studied. Expand
Gap43, Marcks, and Cap23 Modulate Pi(4,5p)2 at Plasmalemmal Rafts, and Regulate Cell Cortex Actin Dynamics through a Common Mechanism
It is suggested that GAP43, myristoylated alanine-rich C kinase substrate, and CAP23 are functionally and mechanistically related PI(4,5)P2 modulating proteins, upstream of actin and cell cortex dynamics regulation. Expand
Cosignaling of NCAM via lipid rafts and the FGF receptor is required for neuritogenesis
It is shown that lipid raft association of NCAM is crucial for activation of the nonreceptor tyrosine kinase pathway and induction of neurite outgrowth in NCAM-triggered mice. Expand
Illuminating cell-cycle progression in the developing zebrafish embryo
The study demonstrates the effectiveness of using the Cul4Ddb1-mediated Cdt1 degradation pathway common to all metazoans for the development of a G1 marker that works in the nonmammalian animal model. Expand
Recombinant Phospholipase Cζ Has High Ca2+ Sensitivity and Induces Ca2+ Oscillations in Mouse Eggs*
The ability of purified mouse PLCζ protein to induce Ca2+ oscillations qualifies P LCζ as a proper candidate of the mammalian egg-activating sperm factor. Expand
Phospholipase C is a key enzyme regulating intracellular calcium and modulating the phosphoinositide balance.
The roles of PLC as a calcium-regulating enzyme and as a modulator of the phosphoinositide balance are focused on. Expand
A Novel Neural Wiskott-Aldrich Syndrome Protein (N-Wasp) Binding Protein, Wish, Induces Arp2/3 Complex Activation Independent of Cdc42
It is suggested that WISH activates Arp2/3 complex through N-WASP–dependent and –independent pathways without Cdc42, resulting in the rapid actin polymerization required for microspike formation. Expand
The Role of EF-hand Domains and C2 Domain in Regulation of Enzymatic Activity of Phospholipase Cζ*
Sperm-specific phospholipase C-ζ (PLCζ) induces Ca2+ oscillations and egg activation when injected into mouse eggs. PLCζ has such a high Ca2+ sensitivity of PLC activity that the enzyme can be activeExpand