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Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3, human

Known as: PI3-Kinase Type 3, PI3K Type 3, PtdIns-3-Kinase Type 3 
Phosphatidylinositol 3-kinase catalytic subunit type 3 (887 aa, ~102 kDa) is encoded by the human PIK3C3 gene. This protein plays a role in the… Expand
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
In response to amino acid availability, the class III PI-3-kinase hVps34 activates the phospholipase PLD and mTORC1 signaling to… Expand
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Highly Cited
2009
Highly Cited
2009
The mammalian Class III PI3K (phosphoinositide 3-kinase), hVps34 [mammalian Vps (vacuolar protein sorting) 34 homologue], is an… Expand
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Highly Cited
2008
Highly Cited
2008
Excess levels of circulating amino acids (AAs) play a causal role in specific human pathologies, including obesity and type 2… Expand
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Highly Cited
2007
Highly Cited
2007
Nutrient overload induces constitutive S6K1 (S6 kinase 1) activation, which leads to insulin resistance by suppressing insulin… Expand
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Review
2007
Review
2007
Recent studies have shown that the nutrient input to the mTOR Complex1/S6K1 signaling pathway is mediated by class 3 PI3K or… Expand
Highly Cited
2006
Highly Cited
2006
Conditional mouse models of polyglutamine diseases, such as Huntington's disease (HD), have revealed that cells can clear… Expand
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Highly Cited
2006
Highly Cited
2006
Beclin 1 was originally identified as a novel Bcl-2-interacting protein, but co-immunoprecipitation studies suggest that the… Expand
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Highly Cited
2006
Highly Cited
2006
The human type III phosphatidylinositol 3-kinase, hVps34, converts phosphatidylinositol (PtdIns) to phosphatidylinositol 3… Expand
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Highly Cited
2005
Highly Cited
2005
Mammalian cells respond to nutrient deprivation by inhibiting energy consuming processes, such as proliferation and protein… Expand
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Highly Cited
2002
Highly Cited
2002
PI 3‐kinases are important regulators of endocytic trafficking. We have previously proposed a model in which the Rab5 GTPase… Expand