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Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3, human
Known as:
PI3-Kinase Type 3
, PI3K Type 3
, PtdIns-3-Kinase Type 3
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Phosphatidylinositol 3-kinase catalytic subunit type 3 (887 aa, ~102 kDa) is encoded by the human PIK3C3 gene. This protein plays a role in the…
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National Institutes of Health
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Related topics
Related topics
13 relations
Autophagy
Autophagy Regulation Pathway
Cytokinesis
Enzyme Gene
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Broader (1)
Class III Phosphatidylinositol 3-Kinase Catalytic Subunit
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
The hVps34‐SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth
R. Bago
,
E. Sommer
,
+7 authors
D. Alessi
EMBO Journal
2016
Corpus ID: 20517264
We explore mechanisms that enable cancer cells to tolerate PI3K or Akt inhibitors. Prolonged treatment of breast cancer cells…
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Review
2012
Review
2012
14-3-3 Proteins are Regulators of Autophagy
Mercedes Pozuelo-Rubio
Cells
2012
Corpus ID: 10637026
14-3-3 proteins are implicated in the regulation of proteins involved in a variety of signaling pathways. 14-3-3-dependent…
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Highly Cited
2011
Highly Cited
2011
Phospholipase D Mediates Nutrient Input to Mammalian Target of Rapamycin Complex 1 (mTORC1)*
Limei Xu
,
Darin Salloum
,
+4 authors
D. A. Foster
Journal of Biological Chemistry
2011
Corpus ID: 42781912
The mammalian target of rapamycin (mTOR) is a critical sensor of nutritional sufficiency. Although much is known about the…
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Review
2011
Review
2011
Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism
J. Dickinson
,
B. Rasmussen
Current opinion in clinical nutrition and…
2011
Corpus ID: 23334862
Purpose of reviewTo highlight the recent research pertaining to the cellular mechanisms linking amino acid availability, mTORC1…
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Highly Cited
2011
Highly Cited
2011
Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase
Mercedes Pozuelo-Rubio
Cell Death and Differentiation
2011
Corpus ID: 12753900
14-3-3s are binding proteins with survival functions in cells by interaction with proteins involved in the regulation of cell…
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Highly Cited
2010
Highly Cited
2010
Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24.
S. Bhutia
,
R. Dash
,
+9 authors
P. Fisher
Cancer Research
2010
Corpus ID: 6370959
Melanoma differentiation-associated gene 7 (mda-7)/interleukin-24 (IL-24) is a unique member of the IL-10 gene family, which…
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Highly Cited
2010
Highly Cited
2010
The RUN Domain of Rubicon Is Important for hVps34 Binding, Lipid Kinase Inhibition, and Autophagy Suppression*
Qiming Sun
,
Jing Zhang
,
+4 authors
Q. Zhong
Journal of Biological Chemistry
2010
Corpus ID: 11160968
The class III phosphatidylinositol 3-kinase (PI3KC3) plays a central role in autophagy. Rubicon, a RUN domain-containing protein…
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Highly Cited
2007
Highly Cited
2007
Regulation of class III (Vps34) PI3Ks.
Y. Yan
,
J. Backer
Biochemical Society Transactions
2007
Corpus ID: 2811157
The class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first identified as a regulator of…
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Highly Cited
2007
Highly Cited
2007
The Inositol Trisphosphate Receptor in the Control of Autophagy
A. Criollo
,
J. Vicencio
,
E. Tasdemir
,
M. Maiuri
,
S. Lavandero
,
G. Kroemer
Autophagy
2007
Corpus ID: 8879048
The second messenger myo-inositol-1,4,5-trisphosphate (IP3) acts on the IP3 receptor (IP3R), an IP3-activated Ca2+ channel of the…
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2003
2003
YXXM Motifs in the PDGF-β Receptor Serve Dual Roles as Phosphoinositide 3-Kinase Binding Motifs and Tyrosine-based Endocytic Sorting Signals*
Haiyan Wu
,
D. Windmiller
,
Ling-Chi Wang
,
J. Backer
Journal of Biological Chemistry
2003
Corpus ID: 23092248
Phosphoinositide 3-kinases (PI 3-kinases) are important regulators of endocytic trafficking. Previous studies have shown that…
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