Pertussis Toxin

Known as: Islet Activating Protein, IAP Pertussis Toxin, Pertussigen 
A class of biologically active protein toxins expressed by Bordetella pertussis, which causes the symptoms of whooping cough. Following bacterial… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Before childhood vaccination was introduced in the 1940s, pertussis was a major cause of infant death worldwide. Widespread… (More)
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Highly Cited
1998
Highly Cited
1998
Vaccine efficacies against typical pertussis after household exposure to Bordetella pertussis were estimated to be 75.4% for an… (More)
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Highly Cited
1994
Highly Cited
1994
BACKGROUND Pertussis toxin is an exotoxin of the A-B class produced by Bordetella pertussis. The holotoxin comprises 952 residues… (More)
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Highly Cited
1993
Highly Cited
1993
Mutants of Bordetella pertussis which are defective in secretion of pertussis toxin were isolated and characterized. The region… (More)
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Review
1992
Review
1992
Pertussis toxin, a protein virulence factor produced by Bordetella pertussis, is composed of an A protomer and a B oligomer. The… (More)
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Highly Cited
1989
Highly Cited
1989
Immunization with chemically detoxified pertussis toxin can prevent severe whooping cough with an efficacy similar to that of the… (More)
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Highly Cited
1988
Highly Cited
1988
Human heart failure is associated with a diminished contractile response to beta-adrenergic agonists. We hypothesized that… (More)
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Highly Cited
1986
Highly Cited
1986
The current pertussis vaccines, although efficacious, in some instances produce undesirable side effects. Molecular engineering… (More)
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Highly Cited
1985
Highly Cited
1985
The cells of the mammalian immune system possess special migratory properties within their in vivo environment, a surveillance… (More)
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Highly Cited
1984
Highly Cited
1984
Treatment of guinea pig neutrophils with pertussis toxin (islet-activating protein; IAP) results in inhibition of N-formyl… (More)
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