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- Publications
- Influence
A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors
Here, we show that the beta-chemokine receptor CKR-5 serves as a cofactor for M-tropic HIV viruses. Expression of CKR-5 with CD4 enables nonpermissive cells to form syncytia with cells expressing… Expand
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
- L. Monticelli, Gregory F. Sonnenberg, +15 authors D. Artis
- Biology
- Nature Immunology
- 1 November 2011
Innate lymphoid cells (ILCs), a heterogeneous cell population, are critical in orchestrating immunity and inflammation in the intestine, but whether ILCs influence immune responses or tissue… Expand
Bayesian community-wide culture-independent microbial source tracking
- Dan Knights, Justin Kuczynski, +6 authors S. Kelley
- Biology, Medicine
- Nature Methods
- 1 September 2011
Contamination is a critical issue in high-throughput metagenomic studies, yet progress toward a comprehensive solution has been limited. We present SourceTracker, a Bayesian approach to estimate the… Expand
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.
BACKGROUND
CCR5 is the major coreceptor for human immunodeficiency virus (HIV). We investigated whether site-specific modification of the gene ("gene editing")--in this case, the infusion of… Expand
Associating microbiome composition with environmental covariates using generalized UniFrac distances
- J. Chen, K. Bittinger, +6 authors Hongzhe Li
- Computer Science, Medicine
- Bioinform.
- 17 June 2012
tl;dr
Topographical continuity of bacterial populations in the healthy human respiratory tract.
- Emily S. Charlson, K. Bittinger, +5 authors R. Collman
- Medicine, Biology
- American journal of respiratory and critical care…
- 15 October 2011
RATIONALE
Defining the biogeography of bacterial populations in human body habitats is a high priority for understanding microbial-host relationships in health and disease. The healthy lung was… Expand
Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses.
- J. Rucker, A. Edinger, +9 authors R. Doms
- Medicine, Biology
- Journal of virology
- 1 December 1997
Human immunodeficiency virus type 1 (HIV-1) requires both CD4 and a coreceptor to infect cells. Macrophage-tropic (M-tropic) HIV-1 strains utilize the chemokine receptor CCR5 in conjunction with CD4… Expand
siRNA-directed inhibition of HIV-1 infection
RNA interference silences gene expression through short interfering 21–23-mer double-strand RNA segments that guide mRNA degradation in a sequence-specific fashion. Here we report that siRNAs inhibit… Expand
Innate Lymphoid Cells Promote Anatomical Containment of Lymphoid-Resident Commensal Bacteria
- Gregory F. Sonnenberg, L. Monticelli, +21 authors D. Artis
- Biology, Medicine
- Science
- 8 June 2012
Protecting Against a Barrier Breach In order to coexist peacefully, a “firewall” exists that keeps the commensal bacteria that reside in our intestines and associated lymphoid tissue contained.… Expand
An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1.
- R. Collman, J. W. Balliet, +4 authors A. Srinivasan
- Biology, Medicine
- Journal of virology
- 1 December 1992
We isolated and molecularly cloned a human immunodeficiency virus type 1 (HIV-1) strain (89.6) which is unusual because it is both macrophage-tropic and extremely cytopathic in lymphocytes. Moreover,… Expand