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Pempidine

Known as: Pempidine [Chemical/Ingredient], Piperidine, 1,2,2,6,6-pentamethyl- 
A nicotinic antagonist most commonly used as an experimental tool. It has been used as a ganglionic blocker in the treatment of hypertension but has… 
National Institutes of Health

Related topics

Related topics

11 relations

Broader (3)

Antihypertensive AgentsGanglionic BlockersNicotinic Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Narrower (1)

pyrilen

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1996
1996
N- and C-terminal substance P fragments modulate striatal dopamine outflow through a cholinergic link mediated by muscarinic receptors
1986
1986
Inhibition by neurosurugatoxin of nicotine-induced antinociception
1985
1985
Evidence for purinergic transmission in mouse bladder and for modulation of responses to electrical stimulation by 5-hydroxytryptamine.
1981
1981
Inhibitory effects of GABA, L-glutamic acid and nicotine on the potassium-evoked release of substance P in substantia nigra slices of the rat.
Highly Cited
1974
Highly Cited
1974
A microinjection study of the control of antidiuretic hormone release by the supraoptic nucleus of the hypothalamus in the cat
1. The release of antidiuretic hormone (ADH) has been studied in the chloralose anaesthetized cat after microinjection of various… 
Highly Cited
1974
Highly Cited
1974
Cholinergic modification of naloxone-induced jumping in morphine dependent mice.
Highly Cited
1963
Highly Cited
1963
THE SITE OF THE 5-HYDROXYTRYPTAMINE RECEPTOR ON THE INTRAMURAL NERVOUS PLEXUS OF THE GUINEA-PIG ISOLATED ILEUM.
Dose/response measurements were made on the guinea-pig isolated ileum with six agonists, acetylcholine, 5-hydroxytryptamine… 
Highly Cited
1963
Highly Cited
1963
THE EFFECTS OF GANGLION-BLOCKING AND POSTGANGLIONIC SYMPATHOLYTIC DRUGS ON PREPARATIONS OF THE GUINEA-PIG VAS DEFERENS.
The contractions of the guinea-pig isolated vas deferens elicited by electrical stimulation of the hypogastric nerve were… 
1960
1960
Interaction between histamine and dichloroisoproterenol, hexamethonium, pempidine, and diphenhydramine, in normal and reserpine-treated heart preparations.
Histamine stimulated the isolated auricles and heart of the guinea-pig. The effect was best seen in auricles which had been… 
1958
1958
The pharmacological actions of pempidine and its ethyl homologue.
Pempidine, and other highly active ganglion blocking agents of the polyalkylpiperidine series, were developed from tertiary… 
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