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Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications.
Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice.
Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects
It is suggested that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2‐mediated uptake of ndolol in the intestine.
Effects of Ginkgo Biloba Extract on Pharmacokinetics and Pharmacodynamics of Tolbutamide and Midazolam in Healthy Volunteers
It is suggested that the combination of GBE and drugs should be cautious in terms of the potential interactions, especially in elderly patients or patients treated with drugs exerting relatively narrow therapeutic windows.
Novel solid self-emulsifying drug delivery system of coenzyme Q₁₀ with improved photochemical and pharmacokinetic behaviors.
Selective Binding of Bladder Muscarinic Receptors in Relation to the Pharmacokinetics of a Novel Antimuscarinic Agent, Imidafenacin, to Treat Overactive Bladder
- S. Yamada, Masanao Seki, Masaki Ogoda, A. Fukata, Miho Nakamura, Yoshihiko Ito
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 February 2011
It is demonstrated that imidafenacin administered orally distributes predominantly to the bladder and exerts more selective and longer-lasting effect on the bladder than other tissues, such as the submaxillary gland, colon, and brain.
Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes.
It is suggested that green tea catechins cause clinically relevant interactions with substrates for CYP2B6 and CYP 2C8 in addition to CYP3A, and EGCG moderately inhibited CYP 3A activity in a noncompetitive manner.
Involvement of dopamine receptors in the anti-immobility effects of dopamine re-uptake inhibitors in the forced swimming test.
Quantitative evaluation of brain distribution and blood-brain barrier efflux transport of probenecid in rats by microdialysis: possible involvement of the monocarboxylic acid transport system.
- Y. Deguchi, K. Nozawa, S. Yamada, Y. Yokoyama, R. Kimura
- BiologyThe Journal of pharmacology and experimental…
- 1 February 1997
The data suggest that the restricted distribution of probenecid in the brain may be ascribed to efficient efflux from the brain ISF, which may be regulated by the monocarboxylic acid transport system at a relatively high ISF concentration.
Green tea extract affects the cytochrome P450 3A activity and pharmacokinetics of simvastatin in rats.
GTE alters the pharmacokinetics of simvastatin acid, probably by inhibiting intestinal CYP3A, through inhibition of midazolam 1'-hydroxylation in rat hepatic microsomes.