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Pelger-Huet Anomaly

Known as: Pelger Huët Nuclear Anomaly, Pelger Huet Anomaly, anomaly huet pelger 
Autosomal dominant anomaly characterized by abnormal ovoid shape GRANULOCYTE nuclei and their clumping chromatin. Mutations in the LAMIN B receptor… 
National Institutes of Health

Related topics

Related topics

10 relations
Anomaly or syndrome, Jordan'sAutosomal dominant inheritanceIn BloodLBR, 4-BP DEL, 32TGGT

Papers overview

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Highly Cited
2003
Highly Cited
2003
Asp1424Asn MYH9 mutation results in an unstable protein responsible for the phenotypes in May-Hegglin anomaly/Fechtner syndrome.
May-Hegglin anomaly (MHA), Fechtner syndrome (FTNS), Sebastian syndrome (SBS), and Epstein syndrome (EPS) are a group of rare… 
Highly Cited
1996
Highly Cited
1996
Autosomal dominant iridogoniodysgenesis anomaly maps to 6p25.
Autosomal dominant iridogoniodysgenesis anomaly (IGDA) is characterized by iris hypoplasia and goniodysgenesis with frequent… 
1993
1993
Fluorescence flow cytometry of human leukocytes in the detection of LDL receptor defects in the differential diagnosis of hypercholesterolemia.
A flow-cytometric method with fluorescence-labeled monoclonal antibodies (MABs) against the low density lipoprotein (LDL… 
Highly Cited
1989
Highly Cited
1989
Interleukin 2 and Soluble Interleukin 2–Receptor Secretion Defect In Vitro in Newly Diagnosed Type I Diabetic Patients
In this study, we investigated whether an interleukin 2 (IL-2) secretion defect by peripheral blood mononuclear cells (PBMCs… 
Highly Cited
1987
Highly Cited
1987
Impaired expression of high affinity interleukin 2 receptor on activated lymphocytes from patients with systemic lupus erythematosus.
Peripheral lymphocytes stimulated with phytohemagglutinin (PHA-blasts) were examined for their responsiveness to exogenous… 
1980
1980
Functional and metabolic studies of polymorphonuclear leukocytes in the congenital Pelger-Huet anomaly.
Polymorphonuclear leukocytes (PMNL) from two individuals with congenital Pelger-Huet anomaly (PHA) were examined to determine… 
Highly Cited
1977
Highly Cited
1977
Expression of the Acid α‐Naphthyl Acetate Esterase Marker by Activated and Secondary T Lymphocytes in Man
Acid α‐naphthyl acetate esterase (ANAE) activity is charecteristic of resting human T lymphocytes. The expression of the ANAE… 
1973
1973
CYCLIC VARIATION IN THE RESPONSE OF LYMPHOCYTES TO PHYTOHEMAGGLUTININ IN HEALTHY INDIVIDUALS
Serial measurements were made of the morphological blast transformation response of lymphocytes to phytohemagglutinin (PHA) in… 
1972
1972
Familial Acute Myeloid Leukaemia with Acquired Pelger-Huët Anomaly and Aneuploidy of C Group
All five members of one generation in an Icelandic family were affected by acute myeloid leukaemia or preleukaemia. Two sibs died… 
Highly Cited
1959
Highly Cited
1959
Acquired pseudo-Pelger anomaly of granulocytic leukocytes.
THE abnormality of granulocytic leukocytes manifested by poor segmentation and condensation of nuclear chromatin was first… 
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