MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis.
The results of this study suggest that miR-124a is a key miRNA in the posttranscriptional regulatory mechanisms of RA synoviocytes.
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease.
Hemoglobin, albumin, and total cholesterol levels, high-density lipoprotein cholesterol values, and body mass index all increased significantly, and fatigue diminished, in patients with MCD.
Primary Levofloxacin Resistance and gyrA/B Mutations Among Helicobacter pylori in Japan
The use of levofloxacin‐containing therapy as a treatment for Helicobacter pylori eradication has been considered a promising regimen, but there is a little information concerning the prevalence of lev ofl Oxacin resistance and this resistance mechanism.
(-)-Epigallocatechin-3-gallate suppresses osteoclast differentiation and ameliorates experimental arthritis in mice.
EGCG suppressed osteoclast differentiation and ameliorated experimental arthritis in mice over the short term and remains to be established whether EGCG is useful for the prevention and treatment of osteoporosis and rheumatoid arthritis.
Expression and Function of Histone Deacetylases in Rheumatoid Arthritis Synovial Fibroblasts
- M. Horiuchi, A. Morinobu, Takaaki Chin, Y. Sakai, M. Kurosaka, S. Kumagai
- Biology, MedicineJournal of Rheumatology
- 1 August 2009
This study provides useful information to develop new HDAC inhibitors for the treatment of RA, and HDAC2 also plays an important role in cell proliferation and apoptosis of RA-SF.
Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome
- K. Arima, A. Kinoshita, K. Yoshiura
- BiologyProceedings of the National Academy of Sciences
- 18 August 2011
The results show that a mutation within a proteasomesome subunit is the direct cause of a human disease and suggest that decreased proteasome activity can cause inflammation.
Meta-analysis: Diagnostic Accuracy of AntiCyclic Citrullinated Peptide Antibody and Rheumatoid Factor for Rheumatoid Arthritis
This systematic review summarized published data on the sensitivity, specificity, and likelihood ratios of RF and anti-CCP antibodies for diagnosing rheumatoid arthritis and summarized results of studies that assessed the associations of these markers with development and radiographic progression of rheumatic arthritis.
Diagnostic Accuracy of Serum 1,3-β-d-Glucan for Pneumocystis jiroveci Pneumonia, Invasive Candidiasis, and Invasive Aspergillosis: Systematic Review and Meta-Analysis
The diagnostic accuracy of the BG assay is high for PJP and moderate for IFI, and the sensitivity for P JP is particularly high, so it can be used as a screening tool forPJP.
Cancer incidence in systemic sclerosis: meta-analysis of population-based cohort studies.
SSc is associated with an increased risk of cancer, particularly lung, liver, hematologic, and bladder cancers, although absolute risk is relatively low and men with SSc have a higher risk of developing cancer than women.
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice
It is shown that peritoneal Ly-1 B cells (also known as B-l cells) are responsible for this autoimmune disease in transgenic mice, and a novel autoantibody production mechanism whereby self-reactive B cellssequestered in compartments free of self-antigens may survive, proliferate and be activated for generation of pathogenic auto-antibodies in autoimmune diseases is proposed.