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Partner and Localizer of BRCA2

Known as: FANCN protein, PALB2 
Partner and localizer of BRCA2 (1186 aa, ~131 kDa) is encoded by the human PALB2 gene. This protein may play roles in cell cycle checkpoints and the… 
National Institutes of Health

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DNA RepairDNA Repair GeneDNA-Binding ProteinsFanconi Anemia

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Abstract P6-08-25: Surgical decision making and clinical outcomes in breast cancer (BC) patients (pts) with germline alterations in moderate risk BC susceptibility genes (CHEK2, PALB2 and ATM)
Background: Multigene panel testing is being used increasingly for BC risk assessment. Following a new BC diagnosis, germline… 
2019
2019
MP41-06 GERMLINE GENETIC TESTING IN MEN WITH PROSTATE CANCER: CLINICAL CHARACTERISTICS AND TESTING OUTCOMES IN A NEWLY INDICATED POPULATION
INTRODUCTION AND OBJECTIVES: Evolving research suggests that up to 12% of metastatic prostate cancer (PC) cases are attributable… 
2016
2016
Abstract PD7-02: Multiplex Identification of genetic etiologies among women with bilateral breast cancer using a 25-gene hereditary cancer panel
Background: Multiple primary cancers within an individual is one of the hallmarks of hereditary cancer predisposition. Technical… 
2016
2016
Pattern of germline variants detected in Sri Lankan patients referred for genetic evaluation of hereditary breast cancer using a multi-gene cancer panel test
Introduction Genes in which germline mutations confer highly or moderately increased risks of cancer are called cancer… 
2016
2016
Abstract P6-06-01: The changing paradigm of hereditary cancer testing: Comparison of tests in 497 women with breast cancer evaluated at an NCI designated cancer center
The Hereditary Cancer Program at Vanderbilt-Ingram Cancer Center (VICC) was established in mid-2012 and provides cancer genetic… 
Review
2016
Review
2016
PALB2: research reaching to clinical outcomes for women with breast cancer
PALB2 has taken its place with bona fide breast cancer susceptibility genes. It is now well established that women who carry loss… 
2015
2015
Abstract P4-12-01: Characterizing the clinical presentation of individuals with pathogenic variants in a breast/ovarian cancer gene panel
Background: Hereditary breast and ovarian cancer (HBOC) is a common indication for referral to cancer genetic counselors. Next… 
2014
2014
966: BRCA1 VUS: an approach to assess functional impact using transcription activation and PALB2 interaction
2012
2012
Rôles du suppresseur de tumeurs PALB2 dans la réparation des cassures double-brin de l'ADN
P A L B 2 is e s s e n t ia l f o r B R C A 2 a n c h o r a g e to n u c le a r s t r u c tu r e s a n d f o r h o m o lo g o u s… 
2009
2009
PALB 2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA 1 and BRCA 2
BRCA1 and BRCA2 are prominently associated with inherited breast and ovarian cancer. The encoded proteins function in DNA damage… 
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