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Familial gastric cancer: overview and guidelines for management*
TLDR
A group of geneticists, gastroenterologists, surgeons, oncologists, pathologists, and molecular biologists gathered to produce consensus statements and guidelines for familial gastric cancer confirmed that the gastric cancers were all of the diffuse type.
International network of cancer genome projects
TLDR
Systematic studies of more than 25,000 cancer genomes will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Breast and Ovarian, Version 2.2017.
TLDR
The NCCN Guidelines Insights summarize the panel's discussion and most recent recommendations regarding risk management for carriers of moderately penetrant genetic mutations associated with breast and/or ovarian cancer.
Esophageal and Esophagogastric Junction Cancers, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.
TLDR
This selection from the NCCN Guidelines for Esophageal and Esophagogastric Junction Cancers focuses on recommendations for the management of locally advanced and metastatic adenocarcinoma of the esophagus and EGJ.
E‐cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer
TLDR
It is demonstrated that germline mutation of the E‐cadherin gene is a common cause of hereditary diffuse gastric cancer and a role for these mutations in the incidence of breast cancer is suggested.
Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer
TLDR
The hypothesis that CDH1 promoter methylation might function as the ‘second genetic hit’ in the genesis of gastric cancers in individuals with hereditary diffuse gastric cancer was suggested.
A practice guideline from the American College of Medical Genetics and Genomics and the National Society of Genetic Counselors: referral indications for cancer predisposition assessment
TLDR
The purpose of this practice guideline is to present a single set of comprehensive personal and family history criteria to facilitate identification and maximize appropriate referral of at-risk individuals for cancer genetic consultation.
A subset of familial colorectal neoplasia kindreds linked to chromosome 9q22.2-31.2
TLDR
Testing for genetic linkage in 53 kindreds in which two or more siblings were affected by age 65 or younger with colon cancer or with advanced colon adenomas that were >1 cm in size or that showed high-grade dysplasia suggests that a single locus can contribute to disease susceptibility in a subset of patients with nonsyndromic forms of familial colorectal neoplasia.
Genetic/familial high-risk assessment: breast and ovarian, version 1.2014.
TLDR
This portion of the NCCN Guidelines includes recommendations regarding diagnostic criteria and management of patients with Cowden Syndrome/PTEN hamartoma tumor syndrome.
Family history-taking in community family practice: Implications for genetic screening
TLDR
Characteristics of physicians, patients, and visits associated with obtaining family history information in community family practice can form the basis for realistic interventions to increase the use of family history in primary care.
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