PYCARD wt Allele

Known as: PYD and CARD Domain Containing wt Allele, ASC, MGC10332 
Human PYCARD wild-type allele is located within 16p12-p11.2 and is approximately 2 kb in length. This allele, which encodes apoptosis-associated… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
0102019902017

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Inflammasomes elicit host defense inside cells by activating caspase-1 for cytokine maturation and cell death. AIM2 and NLRP3 are… (More)
Is this relevant?
Highly Cited
2013
Highly Cited
2013
NLRP3 is a key component of the macromolecular signaling complex called the inflammasome that promotes caspase 1-dependent… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2011
2011
The adaptor ASC contributes to innate immunity through the assembly of inflammasome complexes that activate the cysteine protease… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Some fungal species are opportunistic pathogens that can cause infection in people with compromised immune systems. Activation of… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Mutations in cryopyrin and pyrin proteins are responsible for several autoinflammatory disorders in humans, suggesting that these… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Specific adaptors regulate the activation of initiator caspases; for example, FADD and Apaf-1 engage caspases 8 and 9… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 1
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Toll-like receptors (TLRs) initiate a signalling cascade via association with an adaptor molecule, myeloid differentiation factor… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Cryopyrin, a member of the Nod protein family mutated in familial cold urticaria and Muckle-Wells syndrome, has been recently… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
PYRIN-containing Apaf1-like proteins (PYPAFs) are members of the nucleotide-binding site/leucine-rich repeat (NBS/LRR) family of… (More)
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The PYRIN domain is a recently identified protein-protein interaction domain that is found at the N terminus of several proteins… (More)
Is this relevant?