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PYCARD wt Allele

Known as: PYD and CARD Domain Containing wt Allele, ASC, MGC10332 
Human PYCARD wild-type allele is located within 16p12-p11.2 and is approximately 2 kb in length. This allele, which encodes apoptosis-associated… 
National Institutes of Health

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Related topics

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16p12-p11.2ApoptosisCaspase ActivationHomo sapiens

Broader (1)

PYCARD gene

Papers overview

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2017
2017
ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction-Mediated Intercellular Communication
ASC (apoptosis-associated speck-like protein containing a CARD) is a key adaptor molecule of inflammasomes that mediates… 
2012
2012
Polyacetylene Compound from Cirsium japonicum var. ussuriense Inhibited Caspase-1-mediated IL-1β Expression
Our previous report showed that polyacetylene compound, 1-Heptadecene-11, 13-diyne-8, 9, 10-triol (PA) from the root of Cirsium… 
2011
2011
Demethylation of TMS1 gene sensitizes thyroid cancer cells to TRAIL-induced apoptosis.
CONTEXT TMS1 is a tumor suppressor gene that encodes for caspase recruitment domain containing regulatory protein and has been… 
2010
2010
Epigenetic alterations in disseminated neuroblastoma tumour cells: influence of TMS1 gene hypermethylation in relapse risk in NB patients
PurposeMost neuroblastoma patients over 18 months of age at diagnosis present disseminated disease. The presence of neuroblastoma… 
2010
2010
TMS, a chemically modified herbal derivative of Resveratrol, induces cell death by targeting Bax
Breast cancer recurrence after an initial favorable response to treatment is a major concern for patients who receive hormonal… 
2009
2009
Methylation-sensitive Regulation of TMS1/ASC by the Ets Factor, GA-binding Protein-α*
Epigenetic silencing involving the aberrant DNA methylation of promoter-associated CpG islands is one mechanism leading to the… 
2004
2004
Subcellular localisation of marenostrin/pyrin isoforms carrying the most common mutations involved in familial Mediterranean fever in the presence or absence of its binding partner ASC
Familial Mediterranean fever (FMF) is an autosomal recessive disorder characterised by recurrent episodes of fever and serosal… 
Highly Cited
2003
Highly Cited
2003
Caspy, a Zebrafish Caspase, Activated by ASC Oligomerization Is Required for Pharyngeal Arch Development*
The pyrin domain was identified recently in multiple proteins that are associated with apoptosis and/or inflammation, but the… 
2002
2002
A proapoptotic caspase recruitment domain protein gene, TMS1, is hypermethylated in human breast and gastric cancers.
BACKGROUND Conway et al. demonstrated that methylation of the proapoptotic gene, TMS1, was observed in breast cancer cell lines… 
1985
1985
Transcription of Agrobacterium rhizogenes A4 T-DNA
SummaryTwo distinct segments of transferred DNA (T-DNA) were detected in tumor tissue incited by Agrobacterium rhizogenes strain… 
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