PYCARD gene

Known as: CARD5, PYD and CARD domain containing, TARGET OF METHYLATION-INDUCED SILENCING 1 
This gene plays a role in the regulation of apoptosis.
National Institutes of Health

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Related topics

8 relations
ApoptosisCaspase ActivationPYCARD protein, humanPositive Regulation of Apoptosis
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Broader (1)

Genes

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PYCARD wt Allele

Papers overview

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Highly Cited
2015
Highly Cited
2015
Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species
Administration of mesenchymal stem cells (MSCs) represents a promising treatment option for patients suffering from immunological… (More)
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Highly Cited
2011
Highly Cited
2011
The NALP3/NLRP3 Inflammasome Instigates Obesity-Induced Autoinflammation and Insulin Resistance
The emergence of chronic inflammation during obesity in the absence of overt infection or well-defined autoimmune processes is a… (More)
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Highly Cited
2010
Highly Cited
2010
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
Colitis-associated cancer (CAC) is a major complication of inflammatory bowel diseases. We show that components of the… (More)
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Highly Cited
2010
Highly Cited
2010
Granuloma Formation and Host Defense in Chronic Mycobacterium tuberculosis Infection Requires PYCARD/ASC but Not NLRP3 or Caspase-1
The NLR gene family mediates host immunity to various acute pathogenic stimuli, but its role in chronic infection is not known… (More)
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Highly Cited
2009
Highly Cited
2009
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA.
The nucleotide-binding domain and leucine-rich-repeat-containing (NLR) family of pattern-recognition molecules mediate host… (More)
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Highly Cited
2008
Highly Cited
2008
Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
Aluminium adjuvants, typically referred to as ‘alum’, are the most commonly used adjuvants in human and animal vaccines worldwide… (More)
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Highly Cited
2006
Highly Cited
2006
Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.
Mutations in cryopyrin and pyrin proteins are responsible for several autoinflammatory disorders in humans, suggesting that these… (More)
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Highly Cited
2004
Highly Cited
2004
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
Specific adaptors regulate the activation of initiator caspases; for example, FADD and Apaf-1 engage caspases 8 and 9… (More)
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Highly Cited
2004
Highly Cited
2004
Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC.
Several autoinflammatory disorders are associated with missense mutations within the nucleotide-binding oligomerization domain of… (More)
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Highly Cited
2002
Highly Cited
2002
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
Generation of Interleukin (IL)-1beta via cleavage of its proform requires the activity of caspase-1 (and caspase-11 in mice), but… (More)
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