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PX-12

Known as: 1-methylpropyl 2-imidazolyl disulfide, Thioredoxin-1 Inhibitor PX-12 
An orally bioavailable small molecule with potential antineoplastic activity. Thioredoxin-1 inhibitor PX-12 irreversibly binds to thioredoxin-1 (Trx… 
National Institutes of Health

Related topics

Related topics

2 relations
IV 2 compoundNCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Thioredoxin-1 PEGylation as an In Vitro Method for Drug Target Identification.
  • J. Skalska
  • Methods in molecular biology
  • 2019
  • Corpus ID: 171093632
Redox signaling in the cell, which is essential for cell physiology, involves proteins with free sulfhydryl groups (-SH). Among… 
2015
2015
Moderate Hypoxia Down-Regulates Interleukin-6 Secretion and TLR4 Expression in Human Sw.71 Placental Cells
Background/Aims: The placenta is a vital organ for pregnancy. Many in vitro placental experiments are conducted under 21% O2… 
2013
2013
Effects of the Thioredoxin-1 Inhibitor PX-12 on Blood-Brain Barrier Permeability in the Early Stage of Focal Cerebral Ischemia
Background/Aims: Since a thioredoxin-1 (Trx-1) inhibitor, 1-methylpropyl-2-imidazolyl disulfide (PX-12) which is an antitumor… 
Review
2010
Review
2010
Thioredoxin system modulation by plant and fungal secondary metabolites.
Thioredoxin (Trx) is the major cellular protein disulfide reductase in a broad range of organisms, including humans. Trx… 
2009
2009
Results from phase Ib studies of PX-12, a thioredoxin inhibitor in patients with advanced solid malignancies.
2571 Background: PX-12, a small-molecule inhibitor of Thioredoxin-1 (Trx-1) stimulates apoptosis, down-regulates HIF- 1α, VEGF in… 
Review
2006
Review
2006
Drug evaluation: the thioredoxin inhibitor PX-12 in the treatment of cancer.
Biomira Inc, following its acquisition of ProlX Pharmaceutical Corp, is developing PX-12, an inhibitor of thioredoxin, for the… 
2004
2004
Reversible inhibition of human thioredoxin reductase activity by cytotoxic alkyl 2-imidazolyl disulfide analogues
The thioredoxin/thioredoxin reductase system is important for several aspects of the regulation of cellular proliferation by both… 
2004
2004
Results from Phase I study of PX-12, a thioredoxin inhibitor in patients with advanced solid malignancies.
3089 Background: Thioredoxin-1 (Trx-1) is a cellular redox protein with anti-apoptotic and angiogenic properties. High levels of… 
2002
2002
Enhancement of metabolic oxidative stress-induced cytotoxicity by the thioredoxin inhibitor 1-methylpropyl 2-imidazolyl disulfide is mediated through the ASK1-SEK1-JNK1 pathway.
We observed previously that glucose deprivation induces cytotoxicity, increases the intracellular levels of hydroperoxide, and… 
2002
2002
The redox protein thioredoxin-1 regulates the constitutive and inducible expression of the estrogen metabolizing cytochromes P450 1B1 and 1A1 in MCF-7 human breast cancer cells.
The oxidative metabolites of estrogen have been proposed to play an important role in the development of some human cancers. The… 
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