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PTTG1 wt Allele

Known as: Pituitary Tumor-Transforming 1 wt Allele, TUTR1, hPTTG 
Human PTTG1 wild-type allele is located in the vicinity of 5q35.1 and is approximately 7 kb in length. This allele, which encodes securing protein… 
National Institutes of Health

Related topics

Related topics

7 relations
5q35.1Cell CycleCell Cycle ControlHomo sapiens

Broader (1)

PTTG1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Overexpression of pituitary tumor transforming gene (PTTG) is associated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma.
Review
2007
Review
2007
Pituitary tumor transforming gene: an important gene in normal cellular functions and tumorigenesis.
Pituitary tumor transforming gene (PTTG) is an oncogene which is found to be highly expressed in proliferating cells and in most… 
2007
2007
PTTG expression in different experimental and human prolactinomas in relation to dopaminergic control of lactotropes
BackgroundPituitary tumor transforming gene (pttg) is a novel oncogene that is expressed at higher level in most of the tumors… 
Highly Cited
2006
Highly Cited
2006
Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity.
Genetic instability (GI) is a hallmark feature of tumor development. Securin, also known as pituitary tumor transforming gene… 
2006
2006
Pituitary tumor transforming gene (PTTG) stimulates thyroid cell proliferation via a vascular endothelial growth factor/kinase insert domain receptor/inhibitor of DNA binding-3 autocrine pathway.
CONTEXT Vascular endothelial growth factor (VEGF) exerts its biological effects by binding to the tyrosine kinase receptors VEGF… 
2005
2005
Pituitary tumor-transforming gene (PTTG): a novel target for anti-tumor therapy.
BACKGROUND The proto-oncogene pituitary tumor-transforming gene (PTTG) is described as abundantly over-expressed in a variety of… 
2005
2005
Insulin and IGF‐1 regulate the expression of the pituitary tumor transforming gene (PTTG) in breast tumor cells
Highly Cited
2003
Highly Cited
2003
A potential role for PTTG/securin in the developing human fetal brain
Human securin, known also as PTTG, has established oncogenic and cell cycle regulatory functions. PTTG/securin transforms cells… 
2003
2003
Characterization of the role of Sp1 and NF-Y in differential regulation of PTTG/securin expression in tumor cells.
Highly Cited
1999
Highly Cited
1999
An intronless homolog of human proto-oncogene hPTTG is expressed in pituitary tumors: evidence for hPTTG family.
A novel proto-oncogene, PTTG (Pituitary Tumor Transforming Gene), was isolated in our laboratory by virtue of its increased… 
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