PTTG1 gene

Known as: pituitary tumor-transforming 1, TUMOR-TRANSFORMING 1, tumor-transforming protein 1 
This gene plays a role in cell cycle regulation.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Entry and progression through mitosis has traditionally been linked directly to the activity of cyclin-dependent kinase 1 (Cdk1… (More)
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Highly Cited
2008
Highly Cited
2008
The anaphase promoting complex (APC) or cyclosome is a multi-subunit E3 ubiquitin ligase. Cdc20 (fizzy (fzy)) or p55CDC, and Cdh1… (More)
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Highly Cited
2007
Highly Cited
2007
Inappropriate attachment/tension between chromosomal kinetochores and the kinetochore microtubules activates the spindle assembly… (More)
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Highly Cited
2005
Highly Cited
2005
In mitosis, the spindle checkpoint protein Mad2 averts aneuploidy by delaying anaphase onset until chromosomes align. Here we… (More)
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Highly Cited
2005
Highly Cited
2005
Activation of the anaphase-promoting complex/cyclosome (APC/C) by Cdc20 and Cdh1 leads to ubiquitin-dependent degradation of… (More)
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Highly Cited
2005
Highly Cited
2005
Cdc20 and Cdh1 are the activating subunits of the anaphase-promoting complex (APC), an E3 ubiquitin ligase that drives cells into… (More)
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Highly Cited
2004
Highly Cited
2004
A compromised spindle checkpoint is thought to play a key role in genetic instability that predisposes cells to malignant… (More)
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Highly Cited
2001
Highly Cited
2001
At the onset of anaphase, a caspase-related protease (separase) destroys the link between sister chromatids by cleaving the… (More)
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Highly Cited
2001
Highly Cited
2001
In mitosis, the anaphase-promoting complex (APC) regulates the onset of sister-chromatid separation and exit from mitosis by… (More)
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Highly Cited
1999
Highly Cited
1999
A vertebrate securin (vSecurin) was identified on the basis of its biochemical analogy to the Pds1p protein of budding yeast and… (More)
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