• Publications
  • Influence
Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1).
TLDR
It is recommended that MEN1 patients and their families should be cared for by multidisciplinary teams comprising relevant specialists with experience in the diagnosis and treatment of patients with endocrine tumors. Expand
Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline.
TLDR
This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe both the strength of recommendations and the quality of evidence for diagnosis and treatment of hyperprolactinemia. Expand
Acromegaly: an endocrine society clinical practice guideline.
TLDR
This evidence-based guideline addresses important clinical issues regarding the evaluation and management of acromegaly, including the appropriate biochemical assessment, a therapeutic algorithm, including use of medical monotherapy or combination therapy, and management during pregnancy. Expand
Criteria for cure of acromegaly: a consensus statement.
TLDR
This statement summarizes the consensus achieved in discussions to develop a consensus defining the criteria for cure of acromegaly. Expand
Medical progress: Acromegaly.
  • S. Melmed
  • Medicine
  • The New England journal of medicine
  • 14 December 2006
Guidelines for acromegaly management: an update.
TLDR
The group developed a consensus on the approach to managing acromegaly including appropriate roles for neurosurgery, medical therapy, and radiation therapy in the management of these patients. Expand
A consensus on criteria for cure of acromegaly.
TLDR
Criteria to define active acromegaly and disease control were agreed, and several significant changes were made to the 2000 guidelines. Expand
Long-term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist
TLDR
Pegvisomant is an effective medical treatment for acromegaly and of the patients treated for 12 months or more, 87 of 90 (97%) achieved a normal serum IGF-1 concentration. Expand
Structure, expression, and function of human pituitary tumor-transforming gene (PTTG).
TLDR
Results indicate that human PTTG, a novel oncogene, may function through SH3-mediated signal transduction pathways and activation of growth factor(s), a human pituitary tumor growth-regulating factor. Expand
Pathogenesis of pituitary tumors.
  • S. Melmed
  • Medicine
  • Endocrinology and metabolism clinics of North…
  • 1 March 1999
TLDR
Identification of specific molecular markers of tumor invasiveness and recurrence will allow earlier therapeutic intervention and selection of appropriate follow-up protocols; family screening may become practically feasible; and potent subcellular therapies may be developed for patients with nonfunctioning tumors. Expand
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