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PTPN6 protein, human

Known as: PTP-1C protein, human, Tyrosine-Protein Phosphatase Non-Receptor Type 6, human hematopoietic tyrosine phosphatase 
Tyrosine-protein phosphatase non-receptor type 6 (595 aa, ~66 kDa) is encoded by the human PTPN6 gene. This protein plays a role in both protein… 
National Institutes of Health

Related topics

Related topics

23 relations
ApoptosisB Cell Receptor Signaling PathwayCyclin-Dependent Kinase 11B, humanCytoplasm

Broader (1)

Protein Tyrosine Phosphatase, Non-Receptor Type 6

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Death suppression resolves inflammation
Immunology Impaired signaling of tyrosine-protein phosphatase non-receptor type 6 (PTPN6) has been linked to skin disorders. In… 
2018
2018
PTPN6 regulates the cell-surface expression of TRPM4 channels in HEK293 cells
Transient receptor-potential, cation channel, subfamily M, member 4 (TRPM4) channels regulate a variety of physiological and… 
2017
2017
Role and mechanism of decitabine combined with tyrosine kinase inhibitors in advanced chronic myeloid leukemia cells
Patients with advanced chronic myeloid leukemia (CML) have a poor prognosis, with the use of tyrosine kinase inhibitors (TKIs) to… 
2016
2016
Integrative functional transcriptomic analyses implicate specific molecular pathways in pulmonary toxicity from exposure to aluminum oxide nanoparticles
Abstract Gene expression profiling has developed rapidly in recent years and it can predict and define mechanisms underlying… 
Review
2015
Review
2015
Inhibitory leukocyte immunoglobulin-like receptors in cancer development
Inhibitory leukocyte immunoglobulin-like receptors (LILRB1-5) signal through immunoreceptor tyrosine-based inhibitory motifs… 
2012
2012
ITIM-Containing Inhibitory Receptors Are Required to Balance Oncogenic Signaling Strength in Ph+ ALL
Abstract 291 Background: ITIM (immunoreceptor tyrosine-based inhibition motifs) motifs in the cytoplasmic tail of inhibitory… 
2010
2010
Detection of aberrant SHP-1 promoter methylation, an implication in advanced non-small cell lung cancer.
10627 Background: Epigenetic modification at the promoter-2 region of SHP-1 or PTPN6, a non-receptor protein tyrosine phosphatase… 
2009
2009
Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression
Prostate proliferation is dependent of androgens and many peptide hormones. Recent reports suggest that SSTR2 and SHP-1 were two… 
2004
2004
[Effects of siwu tang on protein expression of bone marrow of blood deficiency mice induced by irradiation].
OBJECTIVE To observe the effects of siwu tang on protein expression of bone marrow of blood deficiency mice and provide the… 
1993
1993
Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice.
The effect of in vivo treatment with anti-CD11b (MAC-1) antibody (Ab) was examined in an inflammatory disease model, the viable… 
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