Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice.

@article{Koo1993AntiCD11bAP,
  title={Anti-CD11b antibody prevents immunopathologic changes in viable moth-eaten bone marrow chimeric mice.},
  author={Gloria C. Koo and Harvey M. Rosen and A. Sirotina and Xiang Ma and Leonard D Shultz},
  journal={Journal of immunology},
  year={1993},
  volume={151 12},
  pages={
          6733-41
        }
}
The effect of in vivo treatment with anti-CD11b (MAC-1) antibody (Ab) was examined in an inflammatory disease model, the viable moth-eaten (mev) mutant mouse. The autosomal recessive mev gene occurred spontaneously as a point mutation of the hematopoietic cell protein tyrosine phosphatase in C57BL/6 mice. Homozygotes (mev/mev) develop a chronic myelomonocytic inflammation, involving accumulation of myelomonocytic cells in lungs and skin, resulting in interstitial pneumonitis and severe edema in… CONTINUE READING

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