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PTPN22 gene

Known as: PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE 8, FORMERLY, PTPN22, LYP 
This gene plays a role in the regulation of the immune system, the development of autoimmunity and the cellular response to pathogens.
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
Protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene polymorphisms are associated with many autoimmune diseases. The… Expand
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Highly Cited
2007
Highly Cited
2007
Gene-gene and gene-environment interactions are key features in the development of rheumatoid arthritis (RA) and other complex… Expand
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Highly Cited
2007
Highly Cited
2007
A variant of the PTPN22 gene, 1858C/T, is associated with an increased risk for the development of a wide array of autoimmune… Expand
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Review
2006
Review
2006
The 620W allelic variant of the intracellular tyrosine phosphatase, PTPN22, is associated with a number of different autoimmune… Expand
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Highly Cited
2005
Highly Cited
2005
Autoimmune disorders constitute a diverse group of phenotypes with overlapping features and a tendency toward familial… Expand
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Highly Cited
2005
Highly Cited
2005
OBJECTIVE The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities for both T cells and B cells. A… Expand
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Highly Cited
2005
Highly Cited
2005
OBJECTIVE To assess the possible association between the PTPN22 gene 1858C-->T polymorphism and the predisposition and clinical… Expand
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Highly Cited
2004
Highly Cited
2004
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting approximately 1% of the adult population… Expand
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Highly Cited
2004
Highly Cited
2004
We genotyped 525 independent North American white individuals with systemic lupus erythematosus (SLE) for the PTPN22 R620W… Expand
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Highly Cited
2004
Highly Cited
2004
In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true positive irrefutable linkage and… Expand
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