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PTPN22 gene

Known as: PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE 8, FORMERLY, PTPN22, LYP 
This gene plays a role in the regulation of the immune system, the development of autoimmunity and the cellular response to pathogens.
National Institutes of Health

Related topics

Related topics

15 relations
Cell Differentiation processCell ProliferationDephosphorylationDiabetes Mellitus, Insulin-Dependent

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PTPN22 wt Allele

Papers overview

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Highly Cited
2009
Highly Cited
2009
Identifying potent, selective protein tyrosine phosphatase inhibitors from a library of Au(I) complexes.
Therapeutic inhibition of protein tyrosine phosphatase activity is a compelling yet challenging approach to the treatment of… 
Highly Cited
2008
Highly Cited
2008
The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus.
OBJECTIVE The C1858T polymorphism in PTPN22 has been associated with the risk of systemic lupus erythematosus (SLE) as well as… 
Highly Cited
2006
Highly Cited
2006
Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.
Highly Cited
2005
Highly Cited
2005
Finnish case–control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis
Several studies have identified the PTPN22 allelic variant 1858 C/T that encodes the R620W amino-acid change as a putative… 
Highly Cited
2005
Highly Cited
2005
Lymphoid tyrosine phosphatase (PTPN22/LYP) variant and Graves’ disease in a Polish population: association and gene dose‐dependent correlation with age of onset
Objective  Susceptibility to Graves’ disease (GD) is to a significant extent determined by genetic factors of which the best… 
Highly Cited
2005
Highly Cited
2005
The R620W C/T polymorphism of the gene PTPN22 is associated with SLE independently of the association of PDCD1
The gene PTPN22 is located on chromosome 1p13 and encodes a protein tyrosine phosphatase called the lymphoid-specific phosphatase… 
Highly Cited
2005
Highly Cited
2005
Protein tyrosine phosphatase gene (PTPN22) polymorphism in multiple sclerosis
Sirs: Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system (CNS) with a complex pathogenesis… 
Review
2005
Review
2005
Genetic susceptibility to type 1 diabetes.
Highly Cited
1997
Highly Cited
1997
Nature of the Transition Structure for Alkene Epoxidation by Peroxyformic Acid, Dioxirane, and Dimethyldioxirane: A Comparison of B3LYP Density Functional Theory with Higher Computational Levels
The performance of the B3LYP density functional theory calculations has been studied for the epoxidation reactions of ethylene… 
Highly Cited
1991
Highly Cited
1991
Inhibition of platelet functions by a monoclonal antibody (LYP20) directed against a granule membrane glycoprotein (GMP-140/PADGEM).
Granule membrane protein (GMP-140), also known as platelet activation-dependent granule-external membrane (PAD-GEM) is an… 
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