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PTPN22 gene

Known as: PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE 8, FORMERLY, PTPN22, LYP 
This gene plays a role in the regulation of the immune system, the development of autoimmunity and the cellular response to pathogens.
National Institutes of Health

Related topics

Related topics

15 relations
Cell Differentiation processCell ProliferationDephosphorylationDiabetes Mellitus, Insulin-Dependent

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PTPN22 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
The PTPN22 C1858T polymorphism is associated with skewing of cytokine profiles toward high interferon-alpha activity and low tumor necrosis factor alpha levels in patients with lupus.
OBJECTIVE The C1858T polymorphism in PTPN22 has been associated with the risk of systemic lupus erythematosus (SLE) as well as… 
Highly Cited
2006
Highly Cited
2006
Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes.
Highly Cited
2006
Highly Cited
2006
Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus.
OBJECTIVE The R620W (1858C-->T) polymorphism in PTPN22 has been implicated in type 1 diabetes mellitus, rheumatoid arthritis… 
Highly Cited
2005
Highly Cited
2005
Finnish case–control and family studies support PTPN22 R620W polymorphism as a risk factor in rheumatoid arthritis, but suggest only minimal or no effect in juvenile idiopathic arthritis
Several studies have identified the PTPN22 allelic variant 1858 C/T that encodes the R620W amino-acid change as a putative… 
Highly Cited
2005
Highly Cited
2005
Protein tyrosine phosphatase gene (PTPN22) polymorphism in multiple sclerosis
Sirs: Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system (CNS) with a complex pathogenesis… 
Review
2005
Review
2005
Genetic susceptibility to type 1 diabetes.
Highly Cited
1997
Highly Cited
1997
Nature of the Transition Structure for Alkene Epoxidation by Peroxyformic Acid, Dioxirane, and Dimethyldioxirane: A Comparison of B3LYP Density Functional Theory with Higher Computational Levels
The performance of the B3LYP density functional theory calculations has been studied for the epoxidation reactions of ethylene… 
1997
1997
A direct ab initio dynamics study of the water‐assisted tautomerization of formamide
Direct ab initio dynamics calculations based on a canonical variational transition-state theory with several multidimensional… 
Highly Cited
1991
Highly Cited
1991
Inhibition of platelet functions by a monoclonal antibody (LYP20) directed against a granule membrane glycoprotein (GMP-140/PADGEM).
Granule membrane protein (GMP-140), also known as platelet activation-dependent granule-external membrane (PAD-GEM) is an… 
Highly Cited
1987
Highly Cited
1987
Significant Reduction in the Binding of a Monoclonal Antibody (LYP 18) Directed Against the IIb/IIIa Glycoprotein Complex to Platelets of Patients Having Undergone Extracorporeal Circulation
Summary Extracorporeal circulation (ECC) used in open heart surgery gives rise to several hemostatic defects. This work… 
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