PTPN22 gene

Known as: PROTEIN-TYROSINE PHOSPHATASE, NONRECEPTOR-TYPE 8, FORMERLY, PTPN22, Lyp 
This gene plays a role in the regulation of the immune system, the development of autoimmunity and the cellular response to pathogens.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2018
020406019842018

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Gene-gene and gene-environment interactions are key features in the development of rheumatoid arthritis (RA) and other complex… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
A variant of the PTPN22 gene, 1858C/T, is associated with an increased risk for the development of a wide array of autoimmune… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
OBJECTIVE The protein tyrosine phosphatase N22 (PTPN22) gene exhibits regulatory activities for both T cells and B cells. A… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Autoimmune disorders constitute a diverse group of phenotypes with overlapping features and a tendency toward familial… (More)
  • table 1
  • figure 1
  • table 2
  • table 3
  • table 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
OBJECTIVE To assess the possible association between the PTPN22 gene 1858C-->T polymorphism and the predisposition and clinical… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
The minor allele of the R620W missense single-nucleotide polymorphism (SNP) (rs2476601) in the hematopoietic-specific protein… (More)
  • table 1
  • figure 1
  • table 4
  • table 5
  • table 6
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting approximately 1% of the adult population… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • table 4
Is this relevant?
Highly Cited
2004
Highly Cited
2004
In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true positive irrefutable linkage and… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
We genotyped 525 independent North American white individuals with systemic lupus erythematosus (SLE) for the PTPN22 R620W… (More)
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Type I diabetes (T1D) is a complex disorder, which arises from the autoimmune destruction of the insulin-secreting β cells of the… (More)
  • figure 1
Is this relevant?