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A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities
TLDR
A SNP in the promoter region of FCRL3, a member of the Fc receptor-like family, that is associated with susceptibility to rheumatoid arthritis is identified and this polymorphism alters the binding affinity of nuclear factor-κB and regulatesFCRL3 expression. Expand
An increased prevalence of Epstein-Barr virus infection in young patients suggests a possible etiology for systemic lupus erythematosus.
TLDR
When considered with other evidence supporting a relationship between Epstein-Barr virus and lupus, these data are consistent with, but do not in themselves establish, Epstein- Barr virus infection as an etiologic factor in l upus. Expand
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
TLDR
The findings indicate that IL-21 polymorphism is a candidate association with SLE and the functional effects of this association, when revealed, might improve the understanding of the disease and provide new therapeutic targets. Expand
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
TLDR
These results establish this TT>A variant as the most likely functional polymorphism responsible for the association between TNFAIP3 and SLE. Expand
Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort
TLDR
Analysis of common TREX1 SNPs revealed a relatively common risk haplotype in European SLE patients with neurological manifestations, especially seizures, with a frequency of 58% in lupus cases compared with 45% in normal controls, and a strong association with anti-nRNP was observed. Expand
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome
TLDR
The results highlight the importance of genes that are involved in both innate and adaptive immunity in Sjögren's syndrome, including TNFAIP3, PTTG1, PRDM1, DGKQ, FCGR2A, IRAK1BP1, ITSN2 and PHIP, among others. Expand
A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus
TLDR
The genetic association between ITGAM and SLE implicates the αMβ2-integrin adhesion pathway in disease development and is associated with systemic lupus erythematosus. Expand
Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
TLDR
The forward genetic studies in human SLE and the mechanistic studies in mouse models establish IRAK1 as a disease gene in lupus, capable of modulating at least 2 key checkpoints in disease development. Expand
Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study.
TLDR
These findings provide evidence of novel genetic susceptibility loci for lupus in African Americans and provide evidence, for the first time, of genome-wide significance for the association between lupu in African American patients and ITGAM and MSH5 (HLA region). Expand
Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies
TLDR
More than 20 robust associations have now been identified and confirmed, providing insights at the molecular level that refine the understanding of the involvement of host immune response processes in systemic lupus erythematosus. Expand
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