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PTPN11 wt Allele

Known as: CFC, SHP-2, BPTP3 
Human PTPN11 wild-type allele is located within 12q24 and is approximately 91 kb in length. This allele, which encodes tyrosine-protein phosphatase… 
National Institutes of Health

Related topics

Related topics

28 relations
12q24Adipocytokine Signaling PathwayCell AdhesionCell Differentiation process

Broader (1)

PTPN11 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Dengue virus infection: Need for appropriate laboratory tests for diagnosis and management of the condition in children during an outbreak.
BACKGROUND Outbreaks of dengue infection occur in several parts of India with clockwork precision closely related to changing… 
Highly Cited
2006
Highly Cited
2006
Effects of a Leukemia-associated Gain-of-Function Mutation of SHP-2 Phosphatase on Interleukin-3 Signaling*
Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias… 
Highly Cited
2000
Highly Cited
2000
Effects of Src Homology Domain 2 (SH2)-Containing Inositol Phosphatase (SHIP), SH2-Containing Phosphotyrosine Phosphatase (SHP)-1, and SHP-2 SH2 Decoy Proteins on FcγRIIB1-Effector Interactions and…
Coaggregation of FcγRIIB1 with B cell Ag receptors (BCR) leads to inhibition of BCR-mediated signaling via recruitment of Src… 
2000
2000
Shp‐2 Specifically Regulates Several Tyrosine‐Phosphorylated Proteins in Brain‐Derived Neurotrophic Factor Signal
Abstract: Brain‐derived neurotrophic factor (BDNF), a member of the neurotrophins, promotes differentiation and survival and… 
1999
1999
IL-2, but not IL-4 and other cytokines, induces phosphorylation of a 98-kDa protein associated with SHP-2, phosphatidylinositol 3'-kinase, and Grb2.
Binding of IL-2 to its receptor activates several biochemical pathways, including JAK-STAT, Ras-mitogen-activated protein kinase… 
1999
1999
Unique features of SHIP, SHP-1 and SHP-2 binding to FcgammaRIIb revealed by surface plasmon resonance analysis.
1996
1996
Localization and down-regulating role of the protein tyrosine phosphatase PTP2C in membrane ruffles of PDGF-stimulated cells.
PTP2C (also known as Syp/SH-PTP2/PTPlD) is a soluble protein tyrosine phosphatase present in most cell types. It interacts… 
1996
1996
Protective immune responses to the E and NS1 proteins of Murray Valley encephalitis virus in hybrids of flavivirus-resistant mice.
The lack of an effective animal model has been a major obstacle in attempts to define the role of humoral and cellular immune… 
1990
1990
A 36 nucleotide deletion mutation in the coding region of the NS1 gene of an influenza A virus RNA segment 8 specifies a temperature-dependent host range phenotype.
1990
1990
Immunoaffinity purification of native dimer forms of the flavivirus non-structural glycoprotein, NS1.
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