Skip to search formSkip to main contentSkip to account menu

PTPN11 wt Allele

Known as: CFC, SHP-2, BPTP3 
Human PTPN11 wild-type allele is located within 12q24 and is approximately 91 kb in length. This allele, which encodes tyrosine-protein phosphatase… 
National Institutes of Health

Related topics

Related topics

28 relations
12q24Adipocytokine Signaling PathwayCell AdhesionCell Differentiation process

Broader (1)

PTPN11 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Effects of a Leukemia-associated Gain-of-Function Mutation of SHP-2 Phosphatase on Interleukin-3 Signaling*
Mutations in SHP-2 phosphatase that cause hyperactivation of its catalytic activity have been identified in human leukemias… 
Highly Cited
2003
Highly Cited
2003
Catalytic-dependent and -independent roles of SHP-2 tyrosine phosphatase in interleukin-3 signaling
SHP-2 tyrosine phosphatase is highly expressed in hematopoietic cells, however, the function of SHP-2 in hematopoietic cell… 
2002
2002
The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.
To study whether protein kinase C (PKC) isoforms can interact with protein-tyrosine-phosphatases (PTPs) which are connected to… 
Highly Cited
2000
Highly Cited
2000
Cytosolic Tyrosine Dephosphorylation of STAT5
STAT5, a member of the signal transducers and activators of transcription (STATs), is important in modulating T cell functions… 
Highly Cited
2000
Highly Cited
2000
Effects of Src Homology Domain 2 (SH2)-Containing Inositol Phosphatase (SHIP), SH2-Containing Phosphotyrosine Phosphatase (SHP)-1, and SHP-2 SH2 Decoy Proteins on FcγRIIB1-Effector Interactions and…
Coaggregation of FcγRIIB1 with B cell Ag receptors (BCR) leads to inhibition of BCR-mediated signaling via recruitment of Src… 
1999
1999
Unique features of SHIP, SHP-1 and SHP-2 binding to FcgammaRIIb revealed by surface plasmon resonance analysis.
1996
1996
Localization and down-regulating role of the protein tyrosine phosphatase PTP2C in membrane ruffles of PDGF-stimulated cells.
PTP2C (also known as Syp/SH-PTP2/PTPlD) is a soluble protein tyrosine phosphatase present in most cell types. It interacts… 
1990
1990
A 36 nucleotide deletion mutation in the coding region of the NS1 gene of an influenza A virus RNA segment 8 specifies a temperature-dependent host range phenotype.
1990
1990
Immunoaffinity purification of native dimer forms of the flavivirus non-structural glycoprotein, NS1.
Highly Cited
1978
Highly Cited
1978
Comparison of the molybdenum centres of native and desulpho xanthine oxidase. The nature of the cyanide-labile sulphur atom and the nature of the proton-accepting group.
The non-functional form of xanthine oxidase known as the desulpho enzyme was compared with the functional enzyme in various ways… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)