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PTPN11 gene

Known as: SHP-2, PTPN11, BPTP3 
This gene plays a role in the regulation of cell signaling. It is involved in cell migration, metabolic control, mitogenic activation and gene… 
National Institutes of Health

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Cell AdhesionCell Differentiation processCell ProliferationCell Proliferation Regulatory Process

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PTPN11 wt Allele

Papers overview

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2019
2019
Abstract 1322: Maximizing the therapeutic potential of SHP2 inhibition with rational combination strategies in tumors driven by aberrant RAS-MAPK signaling
SHP2 (PTPN11) is a protein tyrosine phosphatase and scaffold protein that functions as a convergent node downstream of multiple… 
2018
2018
Abstract 4877: Allosteric inhibition of SHP2 variants containing cancer-associated activating mutations
SHP2 (PTPN11) is a non-receptor protein tyrosine phosphatase and scaffold protein that functions in multiple signal transduction… 
2017
2017
Yolk Sac Erythromyeloid Progenitors Expressing Gain Of Function PTPN 11 Have Functional Features Of JMML But Are Not Sufficient To Cause Disease In Mice Running title : PTPN 11 Mutations in Yolk Sac…
Background: Accumulating evidence suggests the origin of Juvenile Myelomonocytic Leukemia (JMML) is closely associated with fetal… 
2013
2013
The Tyrosine Phosphatase SHP 2 Regulates Sertoli Cell Junction Complexes 1
The blood-testis barrier (BTB) is a large junctional complex composed of tight junctions, adherens junctions, and gap junctions… 
2013
2013
Abstract 350: Inhibition of SHP2 impairs oncogenic activity of EGFR mutants in non-small cell lung cancer.
Activating mutations of epidermal growth factor receptor (EGFR) are found in 5-15% of non small cell lung carcinomas (NSCLC) and… 
2011
2011
Genetic disruption of the PI3K regulatory subunits, p85 alpha, p55 alpha, and p50 alpha partially normalizes gain-of-function PTPN11- induced hypersensitivity to GM-CSF in hematopoietic progenitors
Juvenile Myelomonocytic Leukemia (JMML) is a lethal myeloproliferative disorder (MPD) of children, characterized by… 
2007
2007
SH3BP2, PTPN11 and NF1 mutations resulting in the cherubism phenotype
2006
2006
24 Ectopic Expression of GATA2 Normalizes Aberrant Myelomonocytic Differentiation Induced by Activating PTPN11 Mutations.
Purpose of Study: Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder characterized by overproduction of… 
Review
2005
Review
2005
Mutations of PTPN11 are rare in adult myeloid malignancies.
The PTPN11 gene encodes the phospho-tyrosyine phosphatase protein SHP-2. Constitutional mutations of this gene are involved in… 
1994
1994
Chromosomal localization of an SH2 containing tyrosine phosphatase (SH-PTP3) gene to chromosome 12q24.1.
A genomic DNA fragment, isolated from a human phage library using a human BPTP3 cDNA probe, was shown to be derived from the…