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PTPN11 gene

Known as: SHP-2, PTPN11, BPTP3 
This gene plays a role in the regulation of cell signaling. It is involved in cell migration, metabolic control, mitogenic activation and gene… 
National Institutes of Health

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Related topics

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Cell AdhesionCell Differentiation processCell ProliferationCell Proliferation Regulatory Process

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PTPN11 wt Allele

Papers overview

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Highly Cited
2010
Highly Cited
2010
Angiotensin-II-induced apoptosis requires regulation of nucleolin and Bcl-xL by SHP-2 in primary lung endothelial cells
Angiotensin II (Ang II) is a key proapoptotic factor in fibrotic tissue diseases. However, the mechanism of Ang-II-induced cell… 
Highly Cited
2007
Highly Cited
2007
SHP-2 tyrosine phosphatase inhibits p73-dependent apoptosis and expression of a subset of p53 target genes induced by EGCG
Green tea polyphenol, epigallocatechin-3-gallate (EGCG) differentially regulates the cellular growth of cancer cells in a p53… 
2006
2006
Acquisition of JAK2, PTPN11, and RAS mutations during disease progression in primary myelodysplastic syndrome
Cytokines play an important role in the developmental programs of normal hematopoiesis and leukemia. Signaling through cytokines… 
Highly Cited
2004
Highly Cited
2004
Roles of Gab1 and SHP2 in Paxillin Tyrosine Dephosphorylation and Src Activation in Response to Epidermal Growth Factor*
Epidermal growth factor (EGF) induces paxillin tyrosine dephosphorylation and Src activation, but the signaling pathways that… 
2002
2002
Molecular interactions of SHP1 and SHP2 in IL-3-signalling.
Highly Cited
2001
Highly Cited
2001
A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor*
Although the mechanisms involved in the activation of mitogen-activated protein kinases (MAPK) by receptor tyrosine kinases do… 
2000
2000
Requirement for Protein-tyrosine Phosphatase SHP-2 in Insulin-induced Activation of c-Jun NH2-terminal Kinase*
Mitogen-activated protein kinases, including extracellular signal-regulated kinases and c-Jun NH2-terminal kinases (JNKs), are… 
Highly Cited
1997
Highly Cited
1997
Interleukin-3 Induces the Association of the Inositol 5-Phosphatase SHIP with SHP2*
We recently purified and cloned a 145-kDa protein that becomes tyrosine phosphorylated and associated with Shc in response to… 
Highly Cited
1997
Highly Cited
1997
Signaling Functions of the Tyrosine Residues in the βc Chain of the Granulocyte-Macrophage Colony-Stimulating Factor Receptor
The granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor (GMR) is a heterodimeric receptor expressed by myeloid… 
Highly Cited
1994
Highly Cited
1994
Purification and characterization of PTP2C, a widely distributed protein tyrosine phosphatase containing two SH2 domains.
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