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PTPN11 gene

Known as: SHP-2, PTPN11, BPTP3 
This gene plays a role in the regulation of cell signaling. It is involved in cell migration, metabolic control, mitogenic activation and gene… Expand
National Institutes of Health

Papers overview

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Review
2008
Review
2008
Diverse cellular processes are regulated by tyrosyl phosphorylation, which is controlled by protein-tyrosine kinases (PTKs) and… Expand
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Highly Cited
2007
Highly Cited
2007
Elucidation of the molecular mechanisms underlying carcinogenesis has benefited tremendously from the identification and… Expand
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Highly Cited
2006
Highly Cited
2006
Germline mutations in PTPN11, the gene encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome (NS) and the… Expand
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Highly Cited
2005
Highly Cited
2005
The SH2-containing tyrosine phosphatase Shp2 (PTPN11) is required for growth factor and cytokine signaling. Germline Shp2… Expand
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Highly Cited
2004
Highly Cited
2004
The PTPN11 gene encodes SHP-2 (Src homology 2 domain-containing protein tyrosine Phosphatase), a nonreceptor tyrosine protein… Expand
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Highly Cited
2004
Highly Cited
2004
SHP-2 is a protein tyrosine phosphatase functioning as signal transducer downstream to growth factor and cytokine receptors. SHP… Expand
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Highly Cited
2003
Highly Cited
2003
We report here that individuals with Noonan syndrome and juvenile myelomonocytic leukemia (JMML) have germline mutations in… Expand
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Highly Cited
2002
Highly Cited
2002
Noonan syndrome (NS) is a developmental disorder characterized by facial dysmorphia, short stature, cardiac defects, and skeletal… Expand
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Highly Cited
2001
Highly Cited
2001
Noonan syndrome (MIM 163950) is an autosomal dominant disorder characterized by dysmorphic facial features, proportionate short… Expand
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Highly Cited
2000
Highly Cited
2000
Interleukin-6 is involved in the regulation of many biological activities such as gene expression, cell proliferation, and… Expand
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