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Visualization by Immune Electron Microscopy of a 27-nm Particle Associated with Acute Infectious Nonbacterial Gastroenteritis
A 27-nm particle was observed by immune electron microscopy in an infectious stool filtrate derived from an outbreak in Norwalk, Ohio, of acute infectious nonbacterial gastroenteritis, and this along with other evidence suggested that the particle was the etiological agent of Norwalk gastroEnteritis. Expand
A large array of human monoclonal antibodies to type 1 human immunodeficiency virus from combinatorial libraries of asymptomatic seropositive individuals.
A panel of human monoclonal antibody Fab fragments has been generated against the surface glycoprotein gp120 of type 1 human immunodeficiency virus (HIV) by antigen selection from a randomExpand
Production of infectious human respiratory syncytial virus from cloned cDNA confirms an essential role for the transcription elongation factor from the 5' proximal open reading frame of the M2 mRNA
It should be possible to introduce defined changes into infectious RSV using the M2(ORF1) protein, consistent with its recent identification as a transcription elongation factor and confirms its importance for RSV gene expression. Expand
Dengue type 4 virus mutants containing deletions in the 3' noncoding region of the RNA genome: analysis of growth restriction in cell culture and altered viremia pattern and immunogenicity in rhesus
One or more mutants introduced into this upstream region of full-length DEN4 cDNA may prove to be useful for immunization of humans against disease caused by dengue virus. Expand
Biological Properties of Norwalk Agent of Acute Infectious Nonbacterial Gastroenteritis
Summary Acute infectious nonbacterial gastroenteritis was induced in adult volunteers through three serial passages by oral administration of bacteria-free stool filtrates. This suggested that aExpand
Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease.
A sharp decrease in the rate of virus isolation during the winter of 1965-66 was noted, similar to that reported by others, and the recovery and properties of these 6 viruses form the basis of this report. Expand
Antigenic relationships among human rotaviruses as determined by outer capsid protein VP4.
Evidence was obtained that the serotype-specific domain is located on the VP8 subunit of VP4, which indicates that rotaviruses that exhibited a VP4 amino acid homology of 89% or greater belonged to the same VP4 serotype and subtype as determined by neutralization. Expand
Growth in suckling-mouse brain of "IBV-like" viruses from patients with upper respiratory tract disease.