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PTK2 wt Allele

Known as: FADK, FAK, FAK1 
Human PTK2 wild-type allele is located within 8q24-qter and is approximately 343 kb in length. This allele, which encodes focal adhesion kinase 1… Expand
National Institutes of Health

Papers overview

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Highly Cited
2000
Highly Cited
2000
Most normal cells require adhesion to extracellular matrix for survival, but the molecular mechanisms that link cell surface… Expand
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Highly Cited
1997
Highly Cited
1997
pp125FAK is a tyrosine kinase that appears to regulate the assembly of focal adhesions and thereby promotes cell spreading on the… Expand
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Highly Cited
1996
Highly Cited
1996
FOCAL adhesion kinase1,2 (pp125FAK) is a member of a growing family of structurally distinct protein tyrosine kinases that… Expand
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Highly Cited
1996
Highly Cited
1996
The tyrosine kinase called pp125FAK is believed to play an important role in integrin-mediated signal transduction. pp125FAK is… Expand
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Highly Cited
1995
Highly Cited
1995
Integrin receptors play important roles in organizing the actin- containing cytoskeleton and in signal transduction from the… Expand
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Highly Cited
1995
Highly Cited
1995
Focal adhesion kinase (pp125FAK or FAK) and paxillin colocalize with integrins in structures called focal adhesions. pp125FAK… Expand
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Highly Cited
1994
Highly Cited
1994
The phosphorylation of protein tyrosine kinases (PTKs) on tyrosine residues is a critical regulatory event that modulates… Expand
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Highly Cited
1994
Highly Cited
1994
Changes in cellular growth and dramatic alterations in cell morphology and adhesion are common features of cells transformed by… Expand
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Highly Cited
1993
Highly Cited
1993
The integrin family of heterodimeric cell surface receptors play critical roles in multiple biological processes by mediating… Expand
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Highly Cited
1992
Highly Cited
1992
Expression of the Rous sarcoma virus-encoded oncoprotein, pp60v-src, subverts the normal regulation of cell growth, which results… Expand
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