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Expression analysis of G Protein-Coupled Receptors in mouse macrophages
TLDR
The constitutive or regulated expression in macrophages of several GPCRs identified in this study has not previously been described and are likely to provide important insights into macrophage biology, as well as novel inflammatory pathways that could be future targets for drug discovery.
Tyrosine 394 Is Phosphorylated in Alzheimer's Paired Helical Filament Tau and in Fetal Tau with c-Abl as the Candidate Tyrosine Kinase
TLDR
Results show that phosphorylation of tau on Tyr-394 is a physiological event that is potentially part of a signal relay and suggest that Abl could have a pathogenic role in Alzheimer's disease.
Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family Kinases*
TLDR
It is reported that tau can bind to SH3 domains derived from the p85α subunit of phosphatidylinositol 3-kinase, phospholipase Cγ1, and the N-terminal SH3 of Grb2 as well as to the kinases Fyn, cSrc, and Fgr.
Rapid Tyrosine Phosphorylation of Neuronal Proteins Including Tau and Focal Adhesion Kinase in Response to Amyloid-β Peptide Exposure: Involvement of Src Family Protein Kinases
TLDR
A marked increase in the tyrosine phosphorylation content of numerous neuronal proteins, including tau and putative microtubule-associated protein 2c (MAP2c) is found, indicating that changes in the phosphotyrosine content of cytoplasmic proteins in response to Aβ are potentially an important process.
Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt–PCP–JNK pathway
TLDR
A pathway whereby Aβ induces a clusterin/p53/Dkk1/wnt–PCP–JNK pathway, which drives the upregulation of several genes that mediate the development of AD-like neuropathologies is identified, thereby providing new mechanistic insights into the action of Aβ in neurodegenerative diseases.
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
TLDR
The crystal structure of MAL TIR domain is described and the structure suggests possible dimerization and MyD88-interacting interfaces, and the key interface residues by coimmunoprecipitation using site-directed mutants are confirmed.
TRIF‐dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target
TLDR
The current understanding of the regulatory mechanisms that control TRif‐dependent TLR signaling, the role of the TRIF pathway in different infectious and noninfectious pathologic states, and the potential for manipulating TRIF‐dependentTLR signaling for therapeutic benefit are reviewed.
Structural basis for recruitment of tandem hotdog domains in acyl-CoA thioesterase 7 and its role in inflammation
TLDR
The results link the molecular and cellular functions of Acot7 and identify the enzyme as a candidate drug target in inflammatory disease.
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