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PTGER4 wt Allele

Known as: Prostaglandin E Receptor 4, EP4 Subtype Gene, Prostaglandin E Receptor 4 wt Allele, PGE Receptor, EP4 Subtype Gene 
Human PTGER4 wild-type allele is located in the vicinity of 5p13.1 and is approximately 62 kb in length. This allele, which encodes prostaglandin E2… 
National Institutes of Health

Related topics

Related topics

7 relations
5p13.1G Protein-Coupled Receptor SignalingLigand BindingLipid Binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
The Prostanoid EP4 Receptor and Its Signaling Pathway
The EP4 prostanoid receptor is one of four receptor subtypes for prostaglandin E2. It belongs to the family of G protein–coupled… 
Highly Cited
2011
Highly Cited
2011
Prostaglandin E2 (PGE2) suppresses natural killer cell function primarily through the PGE2 receptor EP4
The COX-2 product prostaglandin E2 (PGE2) contributes to the high metastatic capacity of breast tumors. Our published data… 
Highly Cited
2010
Highly Cited
2010
Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis
Experimental autoimmune encephalomyelitis (EAE) is an animal model of multiple sclerosis (MS). Although prostaglandin (PG… 
Highly Cited
2009
Highly Cited
2009
Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion
Two distinct helper T (TH) subsets, TH1 and TH17, mediate tissue damage and inflammation in animal models of various immune… 
Highly Cited
2009
Highly Cited
2009
EP2 and EP4 receptors differentially mediate MAPK pathways underlying anabolic actions of prostaglandin E2 on bone formation in rat calvaria cell cultures.
Highly Cited
2006
Highly Cited
2006
Prostaglandin E2 Receptor EP4 Contributes to Inflammatory Pain Hypersensitivity
Prostaglandin E2 (PGE2) is both an inflammatory mediator released at the site of tissue inflammation and a neuromodulator that… 
Highly Cited
2006
Highly Cited
2006
Prostaglandin E receptor EP4 antagonism inhibits breast cancer metastasis.
Cyclooxygenase-2 (COX-2) expression in epithelial tumors is frequently associated with a poor prognosis. In a murine model of… 
Highly Cited
2004
Highly Cited
2004
Cyclooxygenase 2 is a key enzyme for inflammatory cytokine‐induced angiogenesis
Cyclooxygenasel (COX1) and COX2 mediate the rate‐limiting step in arachidonic acid me¬tabolism. Expression of COX2 mRNA and… 
Highly Cited
2000
Highly Cited
2000
Prostaglandin E2 Directly Inhibits Bone-Resorbing Activity of Isolated Mature Osteoclasts Mainly Through the EP4 Receptor
Abstract. Prostaglandins (PGs) are well known to be important local factors in regulating bone formation and resorption. PGE2 is… 
Highly Cited
2000
Highly Cited
2000
Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration.
Prostaglandin E(2) (PGE(2)) couples to stimulation of adenylyl cyclase through two distinct G protein-coupled receptors… 
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