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PRPF4B gene

Known as: KIAA0536, Prp4, PR4H 
National Institutes of Health

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PRPF4 genePRPF4B protein, human

Papers overview

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2019
2019
Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes
Ttriple-negative breast cancer (TNBC) is an aggressive and highly metastatic breast cancer subtype. Enhanced TNBC cell motility… 
2013
2013
Evaluation of Cancer Dependence and Druggability of PRP4 Kinase Using Cellular, Biochemical, and Structural Approaches
Background: Little is known about the cancer dependence and druggability of PRP4. Results: Significance of PRP4 catalytic… 
2013
2013
Prp4 kinase is required for proper segregation of chromosomes during meiosis in Schizosaccharomyces pombe.
Chromosome segregation during meiosis is a complex process, which leads to production of four haploid gametes from two precursor… 
2007
2007
Interaction of PRP4 with Krüppel-Like Factor 13 Regulates CCL5 Transcription1
Activation of resting T lymphocytes initiates differentiation into mature effector cells over 3–7 days. The chemokine CCL5… 
1999
1999
spp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p.
We have identified two classical extragenic suppressors, spp41 and spp42, of the temperature sensitive (ts) allele prp4-73. The… 
Highly Cited
1997
Highly Cited
1997
A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs.
We have purified three new human U4/U6-snRNP proteins from HeLa cells. The three proteins formed a tightly bound complex and… 
1997
1997
Mutations within the yeast U4/U6 snRNP protein Prp4 affect a late stage of spliceosome assembly.
We showed previously that the yeast Prp4 protein is a spliceosomal factor that is tightly associated with the U4, U5, and U6… 
1994
1994
Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions.
The PRP4 protein of Saccharomyces cerevisiae is an essential part of the U4/U6 snRNP, a component of the mRNA splicing apparatus… 
1990
1990
An essential gene in Saccharomyces cerevisiae shares an upstream regulatory element with PRP4
ORF2 is an essential gene immediately upstream of PRP4 (formeryl RNA4), a gene involved in nuclear mRNA processing in… 
Highly Cited
1989
Highly Cited
1989
PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle
The Saccharomyces cerevisiae prp mutants (prp2 through prp11) are known to be defective in pre-mRNA splicing at nonpermissive… 
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