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PRPF4B gene

Known as: KIAA0536, Prp4, PR4H 
 
National Institutes of Health

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2 relations
PRPF4 genePRPF4B protein, human

Papers overview

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2013
2013
Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches.
PRP4 kinase is known for its roles in regulating pre-mRNA splicing and beyond. Therefore, a wider spectrum of PRP4 kinase… Expand
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2007
2007
Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription.
Activation of resting T lymphocytes initiates differentiation into mature effector cells over 3-7 days. The chemokine CCL5… Expand
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2004
2004
Human immunodeficiency virus type 2 Gag interacts specifically with PRP4, a serine-threonine kinase, and inhibits phosphorylation of splicing factor SF2.
Using a yeast two-hybrid screen of a T-cell cDNA library to identify cellular proteins that bind to the human immunodeficiency… Expand
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1999
1999
spp42, identified as a classical suppressor of prp4-73, which encodes a kinase involved in pre-mRNA splicing in fission yeast, is a homologue of the splicing factor Prp8p.
We have identified two classical extragenic suppressors, spp41 and spp42, of the temperature sensitive (ts) allele prp4-73. The… Expand
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1997
1997
A new cyclophilin and the human homologues of yeast Prp3 and Prp4 form a complex associated with U4/U6 snRNPs.
We have purified three new human U4/U6-snRNP proteins from HeLa cells. The three proteins formed a tightly bound complex and… Expand
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1997
1997
Mutations within the yeast U4/U6 snRNP protein Prp4 affect a late stage of spliceosome assembly.
We showed previously that the yeast Prp4 protein is a spliceosomal factor that is tightly associated with the U4, U5, and U6… Expand
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1994
1994
Mutational analysis of the PRP4 protein of Saccharomyces cerevisiae suggests domain structure and snRNP interactions.
The PRP4 protein of Saccharomyces cerevisiae is an essential part of the U4/U6 snRNP, a component of the mRNA splicing apparatus… Expand
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1990
1990
Plasmid and chromosomal related toxin polymorphism of Escherichia coli serogroup O 138; plasmid transfer and co-integration with pRP4.
DNA-DNA hybridisation was used to examine 89 isolates of Escherichia coli serogroup O138 for toxin gene content and location… Expand
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1989
1989
PRP4: a protein of the yeast U4/U6 small nuclear ribonucleoprotein particle.
The Saccharomyces cerevisiae prp mutants (prp2 through prp11) are known to be defective in pre-mRNA splicing at nonpermissive… Expand
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1970
1970
Prp4 kinase is required for proper segregation of chromosomes during meiosis in Schizosaccharomyces pombe.
Chromosome segregation during meiosis is a complex process, which leads to production of four haploid gametes from two precursor… Expand
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