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PRO 2000

Known as: 2000 pro, PRO-2000, PRO2000 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

NaphthalenesulfonatesPolymers

Papers overview

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2015
2015
The Low-Cost Compound Lignosulfonic Acid (LA) Exhibits Broad-Spectrum Anti-HIV and Anti-HSV Activity and Has Potential for Microbicidal Applications
Objectives Lignosulfonic acid (LA), a low-cost lignin-derived polyanionic macromolecule, was extensively studied for its anti-HIV… Expand
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Highly Cited
2011
Highly Cited
2011
Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for the prevention of HIV infection in women
Objective:To determine the safety and effectiveness of BufferGel and 0.5% PRO2000 microbicide gels for the prevention of male-to… Expand
Highly Cited
2010
Highly Cited
2010
PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial
Summary Background Innovative prevention strategies for HIV-1 transmission are urgently needed. PRO2000 vaginal gel was… Expand
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Highly Cited
2010
Highly Cited
2010
In Vitro Evaluation of Viability, Integrity, and Inflammation in Genital Epithelia upon Exposure to Pharmaceutical Excipients and Candidate Microbicides
ABSTRACT The use of microbicides is a promising approach for the prevention of HIV-1 transmission. Unfortunately, various… Expand
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2010
2010
Preventing HIV infection: turning the tide for young women
In sub-Saharan Africa the burden of HIV infection falls largely on women who represent about 60% of all people living with the… Expand
Highly Cited
2009
Highly Cited
2009
Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety.
BACKGROUND The lack of biomarkers that are predictive of safety is a critical gap in the development of microbicides. The present… Expand
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2009
2009
Human glutaredoxin-1 catalyzes the reduction of HIV-1 gp120 and CD4 disulfides and its inhibition reduces HIV-1 replication.
Reduction of intramolecular disulfides in the HIV-1 envelope protein gp120 occurs after its binding to the CD4 receptor. Protein… Expand
Highly Cited
2008
Highly Cited
2008
Enhancement of HIV infection by cellulose sulfate.
Cellulose sulfate, a polyanionic compound derived from cotton, has been proposed as a topical microbicide to reduce the sexual… Expand
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2003
2003
Identification of drug‐regulated genes in osteosarcoma cells
The introduction of systemic chemotherapy improved significantly the prognosis of osteosarcoma. Despite this success… Expand
Highly Cited
2001
Highly Cited
2001
`Chemical condoms’ for the prevention of HIV infection: evaluation of novel agents against SHIV89.6PDin vitro and in vivo
Background Vaginal agents which are antiviral and/or inhibit the entry of HIV into the cell could prevent heterosexual… Expand
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