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PRO 2000

Known as: 2000 pro, PRO-2000, PRO2000 
 
National Institutes of Health

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2 relations

Broader (2)

NaphthalenesulfonatesPolymers

Papers overview

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2014
2014
HPTN 035 phase II/IIb randomised safety and effectiveness study of the vaginal microbicides BufferGel and 0.5% PRO 2000 for the prevention of sexually transmitted infections in women.
OBJECTIVES To estimate the effectiveness of candidate microbicides BufferGel and 0.5% PRO 2000 Gel (P) (PRO 2000) for prevention… Expand
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Highly Cited
2011
Highly Cited
2011
Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for the prevention of HIV infection in women.
OBJECTIVE To determine the safety and effectiveness of BufferGel and 0.5% PRO2000 microbicide gels for the prevention of male-to… Expand
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Highly Cited
2010
Highly Cited
2010
PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial
BACKGROUND Innovative prevention strategies for HIV-1 transmission are urgently needed. PRO2000 vaginal gel was efficacious… Expand
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2010
2010
Advances in the Development of Microbicides for the Prevention of HIV Infection
Microbicides are products that can be applied to vaginal or rectal mucosa with the intent of preventing, or at least… Expand
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2009
2009
Human glutaredoxin-1 catalyzes the reduction of HIV-1 gp120 and CD4 disulfides and its inhibition reduces HIV-1 replication.
Reduction of intramolecular disulfides in the HIV-1 envelope protein gp120 occurs after its binding to the CD4 receptor. Protein… Expand
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Highly Cited
2009
Highly Cited
2009
Disruption of tight junctions by cellulose sulfate facilitates HIV infection: model of microbicide safety.
BACKGROUND The lack of biomarkers that are predictive of safety is a critical gap in the development of microbicides. The present… Expand
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2008
2008
PRO-2000, an antimicrobial gel for the potential prevention of HIV infection.
Indevus Pharmaceuticals Inc, under license from Paligent Inc, is developing PRO-2000, an antimicrobial gel for the prevention of… Expand
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2007
2007
Carbohydrate-binding agents efficiently prevent dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-directed HIV-1 transmission to T lymphocytes.
Exposure of HIV-1 to dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN)-expressing B… Expand
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2003
2003
Identification of drug-regulated genes in osteosarcoma cells.
The introduction of systemic chemotherapy improved significantly the prognosis of osteosarcoma. Despite this success… Expand
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Highly Cited
2001
Highly Cited
2001
'Chemical condoms' for the prevention of HIV infection: evaluation of novel agents against SHIV(89.6PD) in vitro and in vivo.
BACKGROUND Vaginal agents which are antiviral and/or inhibit the entry of HIV into the cell could prevent heterosexual… Expand
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