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PRM-151
Known as:
PRM-151/PTX2
, Recombinant Human PTX2
, Recombinant Human Serum Amyloid P/Pentraxin 2
A fully recombinant form of the human pentraxin 2 (PTX2) protein with potential antifibrotic activity. Upon intravenous administration, recombinant…
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National Institutes of Health
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Related topics
Related topics
3 relations
Broader (3)
Homeodomain Proteins
Recombinant Proteins
Serum Amyloid P-Component
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
S828 A RANDOMIZED, DOUBLE BLIND PHASE 2 STUDY OF 3 DIFFERENT DOSES OF PRM-151 IN PATIENTS WITH MYELOFIBROSIS WHO WERE PREVIOUSLY TREATED WITH OR INELIGIBLE FOR RUXOLITINIB
S. Verstovsek
,
M. Talpaz
,
+15 authors
C. Harrison
HemaSphere
2019
Corpus ID: 196542652
2018
2018
PRM-151 in Myelofibrosis: Efficacy and Safety in an Open Label Extension Study
S. Verstovsek
,
Robert Hasserjian
,
+14 authors
Jason Gotlib
Blood
2018
Corpus ID: 80719416
Introduction: PRM-151, a recombinant human pentraxin-2 molecule, has been shown to prevent and reverse fibrosis in animal…
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Review
2018
Review
2018
Management of Myelofibrosis-Related Cytopenias
P. Bose
,
S. Verstovsek
Current Hematologic Malignancy Reports
2018
Corpus ID: 44099015
Purpose of ReviewCytopenias, particularly anemia, are frequently encountered in patients with myelofibrosis. Management of…
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2016
2016
Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease.
N. Nakagawa
,
L. Barron
,
+7 authors
J. Duffield
JCI Insight
2016
Corpus ID: 20028959
Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune…
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Review
2015
Review
2015
PRM-151 in Myelofibrosis: Durable Efficacy and Safety at 72 Weeks
S. Verstovsek
,
R. Mesa
,
+12 authors
J. Gotlib
2015
Corpus ID: 79396609
Background: PRM-151 (PRM) is a recombinant form of pentraxin-2, an endogenous human protein that acts at sites of tissue damage…
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2014
2014
Phase 2 Trial of PRM-151, an Anti-Fibrotic Agent, in Patients with Myelofibrosis: Stage 1 Results
S. Verstovsek
,
R. Mesa
,
+11 authors
J. Gotlib
2014
Corpus ID: 208326204
PRM-151 (PRM) is a recombinant form of Pentraxin-2, an endogenous human protein that acts at sites of tissue damage, inducing…
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Review
2014
Review
2014
Rationale for combination therapy in myelofibrosis.
J. Mascarenhas
Baillière's Best Practice & Research: Clinical…
2014
Corpus ID: 37808568
2014
2014
Phase 2 trial of PRM-151, an antifibrotic agent, in patients with myelofibrosis: Stage 1 results.
S. Verstovsek
,
R. Mesa
,
+10 authors
J. Gotlib
2014
Corpus ID: 78661657
7114 Background: PRM-151 (PRM) is a recombinant form of Pentraxin-2, an endogenous human protein that acts at sites of tissue…
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2013
2013
Characterization and stabilization of recombinant human protein pentraxin (rhPTX-2).
Jing Liu
,
C. Blasie
,
Shuai Shi
,
S. Joshi
,
C. Middaugh
,
D. Volkin
Journal of Pharmacy and Science
2013
Corpus ID: 20744034
The potential human therapeutic protein pentraxin (PTX-2) is a large, glycosylated plasma protein consisting of five monomers…
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2011
2011
Monocyte development inhibitor PRM-151 decreases corneal myofibroblast generation in rabbits.
M. Santhiago
,
V. Singh
,
F. L. Barbosa
,
V. Agrawal
,
S. Wilson
Experimental Eye Research
2011
Corpus ID: 32296887
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