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PRM-151

Known as: PRM-151/PTX2, Recombinant Human PTX2, Recombinant Human Serum Amyloid P/Pentraxin 2 
A fully recombinant form of the human pentraxin 2 (PTX2) protein with potential antifibrotic activity. Upon intravenous administration, recombinant… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

Homeodomain ProteinsRecombinant ProteinsSerum Amyloid P-Component

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Long-term treatment with recombinant human pentraxin 2 protein in patients with idiopathic pulmonary fibrosis: an open-label extension study.
2018
2018
PRM-151 in Myelofibrosis: Efficacy and Safety in an Open Label Extension Study
Introduction: PRM-151, a recombinant human pentraxin-2 molecule, has been shown to prevent and reverse fibrosis in animal… 
2016
2016
Pentraxin-2 suppresses c-Jun/AP-1 signaling to inhibit progressive fibrotic disease.
Pentraxin-2 (PTX-2), also known as serum amyloid P component (SAP/APCS), is a constitutive, antiinflammatory, innate immune… 
Highly Cited
2016
Highly Cited
2016
Recombinant human pentraxin-2 therapy in patients with idiopathic pulmonary fibrosis: safety, pharmacokinetics and exploratory efficacy
Abnormal fibrogenic repair response upon alveolar injury is believed to play an important role in the pathogenesis of idiopathic… 
Review
2015
Review
2015
PRM-151 in Myelofibrosis: Durable Efficacy and Safety at 72 Weeks
Background: PRM-151 (PRM) is a recombinant form of pentraxin-2, an endogenous human protein that acts at sites of tissue damage… 
2014
2014
Phase 2 Trial of PRM-151, an Anti-Fibrotic Agent, in Patients with Myelofibrosis: Stage 1 Results
PRM-151 (PRM) is a recombinant form of Pentraxin-2, an endogenous human protein that acts at sites of tissue damage, inducing… 
Review
2014
Review
2014
Rationale for combination therapy in myelofibrosis.
  • J. Mascarenhas
  • Best practice & research. Clinical haematology
  • 2014
  • Corpus ID: 37808568
Highly Cited
2013
Highly Cited
2013
Recombinant human serum amyloid P in healthy volunteers and patients with pulmonary fibrosis.
2013
2013
Characterization and stabilization of recombinant human protein pentraxin (rhPTX-2).
The potential human therapeutic protein pentraxin (PTX-2) is a large, glycosylated plasma protein consisting of five monomers… 
Review
2010
Review
2010
PRM-151 (recombinant human serum amyloid P/pentraxin 2) for the treatment of fibrosis.
Serum amyloid P or pentraxin 2 (PTX2) is a highly phylogenetically conserved, naturally circulating plasma protein and a soluble… 
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