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PRKG1 protein, human

Known as: cGKI, cGK1, cGMP-Dependent Protein Kinase I 
cGMP-dependent protein kinase 1 (671 aa, ~76 kDa) is encoded by the human PRKG1 gene. This protein is involved in nitric oxide/cyclic GMP-dependent… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (1)

Cyclic GMP-Dependent Protein Kinase Type I
CytoplasmEnzyme GenePRKG1 genePRKG1 wt Allele

Papers overview

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Highly Cited
2015
Highly Cited
2015
Platelet-derived HMGB1 is a critical mediator of thrombosis.
Thrombosis and inflammation are intricately linked in several major clinical disorders, including disseminated intravascular… 
Review
2010
Review
2010
Ceramide in Suicidal Death of Erythrocytes
The suicidal death of erythrocytes or eryptosis is characterized by cell shrinkage, membrane blebbing and cell membrane… 
Highly Cited
2010
Highly Cited
2010
Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes
It has been suggested that cGMP kinase I (cGKI) dampens cardiac hypertrophy. We have compared the effect of isoproterenol (ISO… 
Review
2009
Review
2009
cGMP regulated protein kinases (cGK).
cGMP-dependent protein kinases (cGK) are serine/threonine kinases that are widely distributed in eukaryotes. Two genes--prkg1 and… 
Highly Cited
2007
Highly Cited
2007
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation.
Defective regulation of platelet activation/aggregation is a predominant cause for arterial thrombosis, the major complication of… 
Highly Cited
2004
Highly Cited
2004
Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.
Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin… 
Highly Cited
2000
Highly Cited
2000
Erectile dysfunction in cyclic GMP-dependent kinase I-deficient mice.
The generation of nitric oxide (NO) in penile erectile tissue and the subsequent elevation of cyclic GMP (cGMP) levels are… 
Highly Cited
1999
Highly Cited
1999
Increased Adhesion and Aggregation of Platelets Lacking Cyclic Guanosine 3′,5′-Monophosphate Kinase I
Atherosclerotic vascular lesions are considered to be a major cause of ischemic diseases, including myocardial infarction and… 
Highly Cited
1998
Highly Cited
1998
Defective smooth muscle regulation in cGMP kinase I‐deficient mice
Regulation of smooth muscle contractility is essential for many important biological processes such as tissue perfusion… 
Highly Cited
1993
Highly Cited
1993
Cloning and expression of a novel cyclic GMP-dependent protein kinase from mouse brain.
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