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A family of hyperpolarization-activated mammalian cation channels
The molecular cloning and functional expression of the gene encoding a hyperpolarization-activated cation channel (HAC1) that is present in brain and heart is reported, and this channel exhibits the general properties of Ih channels. Expand
Melanopsin and rod–cone photoreceptive systems account for all major accessory visual functions in mice
The rod–cone and melanopsin systems together seem to provide all of the photic input for these accessory visual functions such as pupillary light reflex and circadian photo-entrainment. Expand
Patient-specific induced pluripotent stem-cell models for long-QT syndrome.
- A. Moretti, M. Bellin, +11 authors K. Laugwitz
- The New England journal of medicine
- 6 October 2010
It was shown that myocytes derived from patients with long-QT syndrome type 1 had an increased susceptibility to catecholamine-induced tachyarrhythmia and that beta-blockade attenuated this phenotype. Expand
Lack of an endothelial store-operated Ca2+ current impairs agonist-dependent vasorelaxation in TRP4−/− mice
A store-operated Ca2+ current is described in vascular endothelium and it is shown that endothelial cells of mice deficient in TRP4 (also known as CCE1) lack this current, showing that TRP 4 is an indispensable component of store- operated channels in native endothelial Cells and that these channels directly provide an Ca2-entry pathway essentially contributing to the regulation of blood vessel tone. Expand
Nomenclature of Voltage-Gated Calcium Channels
A new nomen-ties of the channel complex, the pharmacological and clature of voltage-gated Ca 2ϩ channels, which electrophysiological diversity of Ca 2 ϩ channels arises is more systematic and mimics the well-defined K ϩ primarily from the existence of multiple forms of ␣ 1 sub-channel nomenclature. Expand
Structure and functional expression of a new member of the tetrodotoxin‐sensitive voltage‐activated sodium channel family from human neuroendocrine cells.
A member of a new subclass of the voltage‐activated sodium channel genes has been cloned from the human medullary thyroid carcinoma (hMTC) cell line, demonstrating its expression in hMTC cells, in a C‐cell carcinoma, and in thyroid and adrenal gland. Expand
Role of Hippocampal Cav1.2 Ca2+ Channels in NMDA Receptor-Independent Synaptic Plasticity and Spatial Memory
- S. Moosmang, Nicole Haider, +12 authors T. Kleppisch
- Chemistry, Medicine
- The Journal of Neuroscience
- 26 October 2005
Strong evidence is provided for a role of L-type Ca2+ channel-dependent, NMDAR-independent hippocampal L-LTP in the formation of spatial memory in the behaving animal and for a function of the MAPK/CREB (CRE-binding protein) signaling cascade in linking Cav1.2 channel-mediated Ca 2+ influx to either process. Expand
Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2
The physiological role of the HCN2 subunit is defined as a major determinant of membrane resting potential that is required for regular cardiac and neuronal rhythmicity. Expand
Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues.
- S. Moosmang, J. Stieber, X. Zong, M. Biel, F. Hofmann, A. Ludwig
- Biology, Medicine
- European journal of biochemistry
- 15 March 2001
The results suggest that the heterogeneity of native I(h) currents is generated, at least in part, by the tissue-specific expression of HCN channel genes. Expand
Nomenclature of Voltage-Gated Sodium Channels
The present alphabetical nomenclature does not reveal the structural relationships among the α1 subunits of Ca2+ channels, but it is apparent that these two alphabeticals will overlap at α1L, which may not mediate an L-type Ca2- current and therefore may create confusion. Expand