Skip to search formSkip to main contentSkip to account menu

PPM1D wt Allele

Known as: Protein Phosphatase, Magnesium-Dependent, 1D Gene, Wildtype p53-Induced Phosphatase 1 Gene, Protein Phosphatase 2C, Delta Isoform Gene 
Human PPM1D wild-type allele is located in the vicinity of 17q23.2 and is approximately 64 kb in length. This allele, which encodes protein… 
National Institutes of Health

Related topics

Related topics

9 relations
Breast CarcinomaCell Cycle ProgressionDephosphorylationHydrolysis

Broader (1)

PPM1D gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
WIP1 phosphatase as pharmacological target in cancer therapy
DNA damage response (DDR) pathway protects cells from genome instability and prevents cancer development. Tumor suppressor p53 is… 
Highly Cited
2015
Highly Cited
2015
WIP1 Phosphatase as a Potential Therapeutic Target in Neuroblastoma
The wild-type p53-induced phosphatase 1 (WIP1) is a serine/threonine phosphatase that negatively regulates multiple proteins… 
Highly Cited
2014
Highly Cited
2014
Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction.
Although therapeutic interventions of signal-transduction cascades with targeted kinase inhibitors are a well-established… 
Review
2011
Review
2011
Control of p53 and NF-κB signaling by WIP1 and MIF: role in cellular senescence and organismal aging.
Highly Cited
2009
Highly Cited
2009
WIP1 phosphatase is a negative regulator of NF-κB signalling
Post-translational modifications of NF-κB through phosphorylations enhance its transactivation potential. Much is known about the… 
Highly Cited
2007
Highly Cited
2007
Overexpression of the wip1 gene abrogates the p38 MAPK/p53/Wip1 pathway and silences p16 expression in human breast cancers
Wild-type p53-induced phosphatase (Wip1 or PPM1D) is a serine/threonine protein phosphatase expressed under various stress… 
Highly Cited
2007
Highly Cited
2007
Wip1 protects hydrogen peroxide-induced colonic epithelial barrier dysfunction
Abstract.Tight junctions (TJs) create a paracellular permeability barrier. Although reactive oxygen species have been implicated… 
Review
2004
Review
2004
Wip1-deficient mice are resistant to common cancer genes.
Highly Cited
2002
Highly Cited
2002
Mice Deficient for the Wild-Type p53-Induced Phosphatase Gene (Wip1) Exhibit Defects in Reproductive Organs, Immune Function, and Cell Cycle Control
ABSTRACT The Wip1 gene is a serine/threonine phosphatase that is induced in a p53-dependent manner by DNA-damaging agents. We… 
Highly Cited
1997
Highly Cited
1997
Wip 1 , a novel human protein phosphatase that is induced in response to ionizing radiation in a p 53-dependent manner
Exposure of mammalian cells to ionizing radiation (IR) induces a complex array of cellular responses including cell cycle arrest… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)