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PPM1D gene

Known as: PPM1D, protein phosphatase, Mg2+/Mn2+ dependent 1D, wild-type p53-induced phosphatase 1 
This gene plays a role in the modulation of cell cycle arrest.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Here, we describe the genomic landscape of 496 PTCs… Expand
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Highly Cited
2014
Highly Cited
2014
Several genetic alterations characteristic of leukemia and lymphoma have been detected in the blood of individuals without… Expand
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Highly Cited
2014
Highly Cited
2014
Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the… Expand
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Highly Cited
2013
Highly Cited
2013
Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common… Expand
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Highly Cited
2009
Highly Cited
2009
PURPOSE To identify therapeutic targets in ovarian clear cell carcinomas, a chemoresistant and aggressive type of ovarian cancer… Expand
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Highly Cited
2007
Highly Cited
2007
Medulloblastoma is the most common malignant brain tumor of childhood. Despite numerous advances, clinical challenges range from… Expand
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Highly Cited
2005
Highly Cited
2005
The ATM (ataxia-telangiectasia mutated) and ATR (ataxia-telangiectasia and Rad3-related) kinases respond to DNA damage by… Expand
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Highly Cited
2003
Highly Cited
2003
Neuroblastomas (NBs) show complex patterns of genetic abnormalities, which may include amplification of the MYCN gene, deletion… Expand
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Highly Cited
2002
Highly Cited
2002
Expression of oncogenic Ras in primary human cells activates p53, thereby protecting cells from transformation. We show that in… Expand
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Highly Cited
2002
Highly Cited
2002
We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is… Expand
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