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PNKP gene

Known as: polynucleotide kinase 3'-phosphatase, DNA KINASE, POLYNUCLEOTIDE KINASE 3-PRIME PHOSPHATASE 
National Institutes of Health

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Polynucleotide 3'-phosphatase

Papers overview

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Highly Cited
2018
Highly Cited
2018
A Dual-Enzyme-Assisted Three-Dimensional DNA Walking Machine Using T4 Polynucleotide Kinase as Activators and Application in Polynucleotide Kinase Assays.
T4 polynucleotide kinase (T4 PNK), an intracellular kinase, catalyzes the phosphorylation of 5'-hydroxyl termini in nucleic acids… 
Highly Cited
2014
Highly Cited
2014
A WS2 nanosheet based sensing platform for highly sensitive detection of T4 polynucleotide kinase and its inhibitors.
DNA phosphorylation, catalyzed by polynucleotide kinase (PNK), plays significant regulatory roles in many biological events. Here… 
Highly Cited
2007
Highly Cited
2007
Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination.
Human polynucleotide kinase (hPNK) is a bifunctional enzyme possessing a 5'-DNA kinase activity and a 3'-phosphatase activity… 
Highly Cited
1990
Highly Cited
1990
Response of phage T4 polynucleotide kinase toward dinucleotides containing apurinic sites: design of a 32P-postlabeling assay for apurinic sites in DNA.
We have examined the capacity of bacteriophage T4 polynucleotide kinase (EC 2.7.1.78) to phosphorylate the partially depurinated… 
Highly Cited
1988
Highly Cited
1988
32P-adduct assay: comparative recoveries of structurally diverse DNA adducts in the various enhancement procedures.
A 32P-adduct assay for the measurement of low levels (1 adduct per 10(7) nucleotides) of binding of carcinogens to DNA has been… 
Highly Cited
1986
Highly Cited
1986
Regulatory mechanisms for induction of synthesis of repair enzymes in response to alkylating agents: ada protein acts as a transcriptional regulator.
Expression of the ada and alkA genes, both of which are involved in the adaptive response of Escherichia coli to alkylating… 
Highly Cited
1986
Highly Cited
1986
Solid-phase syntheses of oligodeoxyribonucleoside methylphosphonates.
Oligodeoxyribonucleoside methylphosphonates of defined sequence of the type d-Np(NP)nN, where n is 6-13, are readily prepared on… 
Highly Cited
1982
Highly Cited
1982
Isolation and characterization of two mutant forms of T4 polynucleotide kinase.
Highly Cited
1973
Highly Cited
1973
Reversal of bacteriophage T4 induced polynucleotide kinase action.
Highly Cited
1969
Highly Cited
1969
Use of polynucleotide kinase in fingerprinting non-radioactive nucleic acids.
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