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PNKP gene

Known as: polynucleotide kinase 3'-phosphatase, DNA KINASE, POLYNUCLEOTIDE KINASE 3-PRIME PHOSPHATASE 
 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Maintenance of DNA integrity is crucial for all cell types, but neurons are particularly sensitive to mutations in DNA repair… Expand
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Highly Cited
2008
Highly Cited
2008
Inhibitors of poly (ADP‐ribose)‐polymerase‐1 (PARP) are highly lethal to cells with deficiencies in BRCA1, BRCA2 or other… Expand
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Highly Cited
2004
Highly Cited
2004
Nonhomologous end joining (NHEJ) is the major DNA double‐strand break (DSB) repair pathway in mammalian cells. A critical step in… Expand
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Highly Cited
2004
Highly Cited
2004
Human polynucleotide kinase (hPNK) is a 57.1-kDa monomeric protein with conserved motifs associated with phosphatase and kinase… Expand
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Highly Cited
2001
Highly Cited
2001
XRCC1 protein is required for DNA single-strand break repair and genetic stability but its biochemical role is unknown. Here, we… Expand
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Highly Cited
1999
Highly Cited
1999
Mammalian polynucleotide kinases catalyze the 5′-phosphorylation of nucleic acids and can have associated 3′-phosphatase activity… Expand
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Highly Cited
1994
Highly Cited
1994
We have isolated a large number of polynucleotide kinase ribozymes from a pool of RNA molecules consisting of an ATP-binding… Expand
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Highly Cited
1990
Highly Cited
1990
Many plants, as well as other organisms, accumulate betaine (N,N,N-trimethylglycine) as a nontoxic or protective osmolyte under… Expand
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Highly Cited
1987
Highly Cited
1987
Host tRNAs cleaved near the anticodon occur specifically in T4‐infected Escherichia coli prr strains which restrict… Expand
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Highly Cited
1983
Highly Cited
1983
The pathogenicity of fixed rabies virus strains for adult mice depends on the presence of an antigenic determinant on the viral… Expand
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