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DNA sequencing with chain-terminating inhibitors.
- F. Sanger, S. Nicklen, A. Coulson
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 1 December 1977
A new method for determining nucleotide sequences in DNA is described, which makes use of the 2',3'-dideoxy and arabinon nucleoside analogues of the normal deoxynucleoside triphosphates, which act as specific chain-terminating inhibitors of DNA polymerase.
Sequence and organization of the human mitochondrial genome
The complete sequence of the 16,569-base pair human mitochondrial genome is presented and shows extreme economy in that the genes have none or only a few noncoding bases between them, and in many cases the termination codons are not coded in the DNA but are created post-transcriptionally by polyadenylation of the mRNAs.
Complete sequence of bovine mitochondrial DNA. Conserved features of the mammalian mitochondrial genome.
A rapid method for determining sequences in DNA by primed synthesis with DNA polymerase.
Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing.
A Rapid Method for Determining Sequences in DNA by Primed Synthesis with DNA Polymerase
Nucleotide sequence of bacteriophage lambda DNA.
Nucleotide sequence of bacteriophage phi X174 DNA.
A DNA sequence for the genome of bacteriophage phi X174 of approximately 5,375 nucleotides has been determined using the rapid and simple 'plus and minus' method. The sequence identifies many of the…
Nucleotide sequence of bacteriophage φX174 DNA
The sequence identifies many of the features responsible for the production of the proteins of the nine known genes of the organism, including initiation and termination sites for the proteins and RNAs.